Human Sperm Testicular Angiotensin Converting Enzyme Helps Determine Human Embryo Quality
dc.contributor.author | Gianzo Citores, Marta | |
dc.contributor.author | Urizar Arenaza, Itziar | |
dc.contributor.author | Muñoa Hoyos, Iraia | |
dc.contributor.author | Larreategui, Zaloa | |
dc.contributor.author | Garrido, Nicolás | |
dc.contributor.author | Casis Sáenz, Luis | |
dc.contributor.author | Irazusta Astiazaran, Jon | |
dc.contributor.author | Subirán Ciudad, Nerea | |
dc.date.accessioned | 2018-11-14T11:32:20Z | |
dc.date.available | 2018-11-14T11:32:20Z | |
dc.date.issued | 2018-06-05 | |
dc.identifier.citation | Asian Journal Of Andrology 20 : (2018) // Article ID PMID 29873314 | es_ES |
dc.identifier.issn | 1008-682X | |
dc.identifier.issn | 1745-7262 | |
dc.identifier.uri | http://hdl.handle.net/10810/29648 | |
dc.description.abstract | Angiotensin-converting enzyme functions in the male reproductive system, but the extent of its function in reproduction is not fully understood. The primary objective of this work was to investigate the relationship between the testicular isoform of angiotensin-converting enzyme present in human spermatozoa and semen parameters, human embryo quality, and assisted reproduction success. A total of 81 semen samples and 635 embryos from couples undergoing oocyte donation cycles at the IVI Bilbao Clinic were analyzed. Semen parameters, embryos quality, and blastocyst development were examined according to the World Health Organization standards and the Spanish Association of Reproduction Biology Studies criteria. The percentage of testicular angiotensin-converting enzyme-positive spermatozoa and the number of molecules per spermatozoon were analyzed by flow cytometry. Both parameters were inversely correlated with human sperm motility. Higher percentages of testicular angiotensin-converting enzyme-positive spermatozoa together with fewer enzyme molecules per spermatozoon were positively correlated with better embryo quality and development. Our results suggest that embryos with a higher implantation potential come from semen samples with higher percentages of testicular angiotensin-converting enzyme-positive cells and fewer enzyme molecules per spermatozoon. Based on these findings, we propose that testicular angiotensin-converting enzyme could be used to aid embryologists in selecting better semen samples for obtaining high-quality blastocysts during in vitro fertilization procedures. | es_ES |
dc.description.sponsorship | The authors thank Alejandro Diez, Ph.D., technician of the Analytical and High-Resolution Microscopy and Cytometry Laboratory in Biomedicine Service of the University of Basque Country (UPV/EHU), for his technical assistance with samples processing by flow cytometry. This study was supported by grants from the Basque Government (GIC12/173; to MG and IMH) and University of the Basque Country (UPV/EHU) (EHUA14/17; to MG and IUA). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wolters Kluwer Medknow | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es/ | * |
dc.subject | angiotensin-converting enzyme | es_ES |
dc.subject | ART | es_ES |
dc.subject | embryonic development | es_ES |
dc.subject | human sperm | es_ES |
dc.subject | male fertility | es_ES |
dc.subject | ejaculated human spermatozoa | es_ES |
dc.subject | live birth-rates | es_ES |
dc.subject | reproductive technologies | es_ES |
dc.subject | male-infertility | es_ES |
dc.subject | male-fertility | es_ES |
dc.subject | ACE | es_ES |
dc.subject | oocyte | es_ES |
dc.subject | testis | es_ES |
dc.subject | fertilization | es_ES |
dc.subject | capacitation | es_ES |
dc.title | Human Sperm Testicular Angiotensin Converting Enzyme Helps Determine Human Embryo Quality | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms | es_ES |
dc.rights.holder | Atribución-NoComercial-CompartirIgual 3.0 España | * |
dc.relation.publisherversion | http://www.ajandrology.com/temp/AsianJAndrol205498-4074506_111905.pdf | es_ES |
dc.identifier.doi | 10.4103/aja.aja_25_18 | |
dc.departamentoes | Filosofía | es_ES |
dc.departamentoeu | Fisiologia | es_ES |
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Except where otherwise noted, this item's license is described as This is an open access journal, and articles are distributed under the terms of the
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which
allows others to remix, tweak, and build upon the work non-commercially, as long
as appropriate credit is given and the new creations are licensed under the identical
terms