Analisi farmakozinetiko/farmakodinamikoa antimikrobianoen erabilera hobetzeko gaixo larrietan

Abstract

Azken urteotan infekzioen tratamendua mundu mailako osasun publi-koko arazo bilakatu da, erresistentzien garapenaren ondorioz, bakterio multirresisten-teen agerpena izugarri igo baita. Antibiotiko berrien gabeziak merkatuan daudenen do-sifikazioen optimizazioaren premia areagotzen du. Zenbait pazientetan, gaixo larrietan esaterako, aipatutakoa egitea bereziki zaila suerta daiteke. Izan ere, beraien egoera fi-siopatologikoa dela eta, medikamentuen farmakozinetika eta farmakodinamia eralda-tuta daukate. Analisi farmakozinetiko/farmakodinamikoak, Monte Carlo simulazioekin batera, dosifikazio-erregimenen optimizazioa ahalbidetzen du. Horrela, tratamenduaren arrakasta bermatu eta erresistentzien agerpena ekiditen da.; Nowadays, the treatment of infectious diseases has become a global health issue, due to multi-resistant antibiotic bacteria. The lack of new antibiotics enhances urgent need for current antimicrobials’ dosing regimens optimization. This could be-come an extremely challenging duty when treating some kind of patients, such as the critically ill; as due to their physiophatological situation, both pharmacokinetics and pharmacodynamics might be altered. PK/PD analysis, together with Monte Carlo Sim-ulation, might be a useful tool in order to optimize dosing regimens of antibiotic agents and, therefore, improve clinical outcome and diminish emergence of resistances.