Active Surveillance for Prostate Cancer as treatment modality: experience at Basurto University Hospital

Abstract

[EN] Introduction: Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer death in men worldwide. Different treatment modalities are available for low-risk localized PC, one of them being Active Surveillance,which is defined as a monitoring strategy for patients with prostatecancer with the aim of deferring curative treatment.Several protocols have been proposed.Materials and methods:This study includes all patients diagnosed with PC that have undergone or currently undergo AS as treatment modality at Basurto University Hospital between September 2014 and March 2019.Once a database was designed and data was collected, descriptive and comparative (variables related to progression) analyses wereperformed.Results:These variables were notrelated to PC progression: age at diagnosis, BMI, ECOG, PC family history, alpha-blockers, statins, total PSA, PSA density, F/T PSA, clinical stage, number of previous biopsies, percentage of positive cylinders, larger lengthaffecting a cylinder, HGPIN, ASAP, IIEF score. CCI score (a higher score was seen on patients that had progressed)was related to progression, and lose of QOL after RRP (measured using IIEF) was proved.Conclusions:Astrict selection of patients should be done when considering AS as a treatment option, specially focusing on the estimated 10-year survival. Additionally, the deferral of active treatment can be justified by seeing the results obtained regarding QOL deterioration after RRP.The results of this study should be further studiedby extending this study and including more patients into it.Furthermore, longer follow-up is needed in order to know oncological outcomes.