Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes

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Date
2021-11-28
Author
Fu, Bo
Escorihuela, Jorge
Han, Jianlin ORCID
Fustero, Santos ORCID
Barrio, Pablo
Sodeoka, Mikiko
Kawamura, Shintaro
Sorochinsky, Alexander ORCID
Soloshonok, Vadym Anatolievch ORCID
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Molecules 26(23) : (2021) // Article ID 7221
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http://hdl.handle.net/10810/54420
Abstract
Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012−2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes.
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2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).