Factores de riesgo y supervivencia libre de tumor en pacientes con trasplante renal de cadáver

Abstract

[Background] There is an agreement in the fact that cancer incidence in transplant recipients increases at a rate disproportionately greater than in the general population. Several clinical studies have identified cancer risk factors, such as age, male gender, tobacco, UV radiation, viral infections, previous malignancies, intensity and duration of immunosuppressive therapies, HLA matches and time in waiting list.

[Aims of the study]

[General aim] To analyze risk factors associated to "de novo" cancers in transplant recipients and to define putative preventive strategies.

[Specific aims] To evaluate tumor incidence and its relationship with the time from grafting. To analyze its relationship with changes in risk factors along the post-transplantation period. To identify clinical and statistically significant cancer risk factors. To link the free-tumor-period with patient survival time, in different kind of cancers. To set up a statistic model to study the different risk factors.

[Patients and Methods] Retrospective analysis of a cohort from 1,979 renal transplant patients, fulfilling the criteria of developing "de novo" cancer in the post-transplant period. Analyzing clinical and oncology parameters and performing a new and specific statistic tool.