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Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions

dc.contributor.authorTrejo, Ángela
dc.contributor.authorMasdeu Margalef, Carme
dc.contributor.authorSerrano Pérez, Irene
dc.contributor.authorPedrola, Marina
dc.contributor.authorJuanola, Narcís
dc.contributor.authorGhashghaei, Ouldouz
dc.contributor.authorJiménez Galisteo, Guadalupe
dc.contributor.authorLavilla, Rodolfo
dc.contributor.authorPalacios Gambra, Francisco Javier ORCID
dc.contributor.authorAlonso Pérez, Concepción Estibaliz ORCID
dc.contributor.authorViñas, Miguel
dc.date.accessioned2023-01-24T17:05:42Z
dc.date.available2023-01-24T17:05:42Z
dc.date.issued2023-01-03
dc.identifier.citationAntibiotics 12(1) : (2023) // Article ID 83es_ES
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10810/59456
dc.description.abstractNew antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria.es_ES
dc.description.sponsorshipThe work was funded in part by the Marató TV3 Foundation 2018 (#20183530), the National Research Foundation (NRF) (Blue Sky’s Research Programme # 120386), the Ministerio de Ciencia e Innovación, the Spain and European Regional Development Fund (EDFR) (PID2019-107991RB-I00, and PID2021-122558OB-I00, UE) and by Gobierno Vasco, Universidad del País Vasco (GV, IT1701-22; UPV). Technical and human support provided by SGIker (UPV/EHU) is also acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2019-107991RB-I00es_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2021-122558OB-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectantibioticses_ES
dc.subjectdrugses_ES
dc.subjectmulticomponent reactionses_ES
dc.subjectmycobacteriaes_ES
dc.subjectresistant bacteriaes_ES
dc.titleEfficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactionses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2023-01-20T14:22:39Z
dc.rights.holder© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/12/1/83es_ES
dc.identifier.doi10.3390/antibiotics12010083
dc.departamentoesQuímica orgánica I
dc.departamentoeuKimika organikoa I


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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).
Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).