Lithium levels and lifestyle in patients with bipolar disorder: a new tool for self-management
dc.contributor.author | Zorrilla Martínez, Iñaki | |
dc.contributor.author | López Zurbano, Saioa | |
dc.contributor.author | Alberich, Susana | |
dc.contributor.author | Barbero Martínez, Ismael | |
dc.contributor.author | López Peña, María Purificación | |
dc.contributor.author | García Corres, E. | |
dc.contributor.author | Chart Pascual, Juan Pablo | |
dc.contributor.author | Crespo, José Manuel | |
dc.contributor.author | De Dios, C. | |
dc.contributor.author | Balanzá Martínez, Vicent | |
dc.contributor.author | González Pinto Arrillaga, Ana María | |
dc.date.accessioned | 2023-03-27T16:58:44Z | |
dc.date.available | 2023-03-27T16:58:44Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | International Journal of Bipolar Disorders 11(1) : (2023) // Article ID 11 | es_ES |
dc.identifier.issn | 2194-7511 | |
dc.identifier.uri | http://hdl.handle.net/10810/60517 | |
dc.description.abstract | BACKGROUND: Patients should get actively involved in the management of their illness. The aim of this study was to assess the influence of lifestyle factors, including sleep, diet, and physical activity, on lithium levels in patients with bipolar disorder. METHODS: A multicenter study was performed. In total, 157 lithium measurements were done biweekly in a sample of 65 patients (35 women) over 6weeks. Lifestyle, based on total sleep hours and physical activity, was assessed by actigraphy. Diet was evaluated using the Mediterranean Lifestyle Index (Medlife). RESULTS: 35.4% of patients had a normal weight. The mean Medlife score was 14.5 (±2.5) (moderate-good adherence to Mediterranean diet). BMI, daily dose of lithium and intensity of physical activity had a combined effect on lithium levels, after adjustment for other variables. Patients who practiced intense physical exercise, who took lower doses and had a higher BMI exhibited lower levels of lithium. CONCLUSIONS: Higher physical activity and BMI contribute to lower lithium levels. Patients should be made aware of these relationships to improve their perception of control and self-management. Lifestyle-based interventions contribute to establishing a more personalized medicine. | es_ES |
dc.description.sponsorship | This work was supported by Carlos III Health Research Institute [Grant numbers PI18/01055, PI19/00569, PI21/00713 (co-financed by the European Regional Development Fund (ERDF)/European Social Fund ‘Investing in your future’]. Foundation for Health Innovation and Research (BIOEF18/020); Networking Center for Biomedical Research in Mental Health (CIBERSAM), the Basque Government [Grant number 2017111104] and the University of the Basque Country [Grant number 321218ELCY]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | bipolar disorder | es_ES |
dc.subject | healthy diet | es_ES |
dc.subject | lifestyle factors | es_ES |
dc.subject | lithium | es_ES |
dc.subject | sleep | es_ES |
dc.subject | wearable | es_ES |
dc.title | Lithium levels and lifestyle in patients with bipolar disorder: a new tool for self-management | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023. The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-023-00291-x | es_ES |
dc.identifier.doi | 10.1186/s40345-023-00291-x | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as © 2023. The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.