Cost-utility analysis of the UPRIGHT intervention promoting resilience in adolescents
dc.contributor.author | Mar Medina, Javier | |
dc.contributor.author | Larrañaga Uribeetxebarria, Igor | |
dc.contributor.author | Odriozola, Oliver | |
dc.contributor.author | González Pinto Arrillaga, Ana María | |
dc.contributor.author | Las Hayas, Carlota | |
dc.contributor.author | Fullaondo, Ane | |
dc.contributor.author | Izco Basurko, Irantzu | |
dc.contributor.author | Alonso, Jordi | |
dc.contributor.author | Zorrilla Martínez, Iñaki | |
dc.contributor.author | Fernández Sevillano, Jessica | |
dc.contributor.author | De Manuel, Esteban | |
dc.contributor.author | UPRIGHT Consortium | |
dc.date.accessioned | 2023-05-04T15:21:46Z | |
dc.date.available | 2023-05-04T15:21:46Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | BMC Psychiatry 23(1) : (2023) // Article ID 178 | es_ES |
dc.identifier.issn | 1471-244X | |
dc.identifier.uri | http://hdl.handle.net/10810/61034 | |
dc.description.abstract | Background As mental health in adulthood is related to mental status during adolescence, school-based interventions have been proposed to improve resilience. The objective of this study was to build a simulation model representing the natural history of mental disorders in childhood, adolescence and youth to estimate the cost-effectiveness of the UPRIGHT school-based intervention in promoting resilience and mental health in adolescence. Methods We built a discrete event simulation model fed with real-world data (cumulative incidence disaggregated into eight clusters) from the Basque Health Service database (609,381 individuals) to calculate utilities (quality-adjusted life years [QALYs]) and costs for the general population in two scenarios (base case and intervention). The model translated changes in the wellbeing of adolescents into different risks of mental illnesses for a time horizon of 30 years. Results The number of cases of anxiety was estimated to fall by 5,125 or 9,592 and those of depression by 1,269 and 2,165 if the effect of the intervention lasted 2 or 5 years respectively. From a healthcare system perspective, the intervention was cost-effective for all cases considered with incremental cost-utility ratios always lower than €10,000/QALY and dominant for some subgroups. The intervention was always dominant when including indirect and non-medical costs (societal perspective). Conclusions Although the primary analysis of the trial did not did not detect significant differences, the UPRIGHT intervention promoting positive mental health was dominant in the economic evaluation from the societal perspective. Promoting resilience was more cost-effective in the most deprived group. Despite a lack of information about the spillover effect in some sectors, the economic evaluation framework developed principally for pharmacoeconomics can be applied to interventions to promote resilience in adolescents. As prevention of mental health disorders is even more necessary in the post-coronavirus disease-19 era, such evaluation is essential to assess whether investment in mental health promotion would be good value for money by avoiding costs for healthcare providers and other stakeholders. | es_ES |
dc.description.sponsorship | This work has been conducted within the UPRIGHT project, which is funded by the European Union’s Horizon 2020 framework programme for research and innovation under grant agreement No. 754919. This paper reflects only the views of the authors, and the European Union is not responsible for any use that may be made of the information it contains. The funding body has had no role in the study design, writing of the protocol or the decision to submit the paper for publication. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMC | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/2020/754919 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | adolescents health | es_ES |
dc.subject | resilience | es_ES |
dc.subject | mental health | es_ES |
dc.subject | mental disorders | es_ES |
dc.subject | prevention | es_ES |
dc.subject | simulation model | es_ES |
dc.subject | health policy | es_ES |
dc.title | Cost-utility analysis of the UPRIGHT intervention promoting resilience in adolescents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-023-04665-4 | es_ES |
dc.identifier.doi | 10.1186/s12888-023-04665-4 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.