Abstract
Orthogonal arrays are of great importance in mathematical sciences. This paper analyses a certain practical
advantage of quasi-difference matrices over difference matrices to obtain orthogonal arrays with given
parameters. We also study the existence of quasi-difference matrices over cyclic groups originating orthogonal
arrays with 𝑡 = 2 and 𝜆 = 1, proving their existence for some parameters sets. Moreover, we present an Integer
Programming model to find such quasi-difference matrices and also a Bimodal Local Search algorithm to obtain
them. We provide a conjecture related to the distributions of differences along rows and columns of arbitrary
square matrices with entries in a cyclic group in positions outside the main diagonal which shows an intriguing
symmetry, and we prove it when the matrix is a quasi-difference matrix