BackExaminar por departamento (cas.) "Medicina"
Now showing items 21-40 of 190
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Association between CASP8-652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study
Pardini, Barbara; Verderio, Paolo; Pizzamiglio, Sara; Nici, Carmela; Maiorana, Maria Valeria; Naccarati, Alessio; Vodickova, Ludmila; Vymetalkova, Veronika; Veneroni, Silvia; Daidone, Maria Grazia; Ravagnani, Fernando; Bianchi, Tiziana; Bujanda Fernández de Pierola, Luis
; Carracedo, Angel; Castells, Antoni; Ruiz Ponte, Clara; Morreau, Hans; Howarth, Kimberley; Jones, Angela; Castellví-Bel, Sergi; Li, Li; Tomlinson, Ian; Van Wezel, Tom; Vodicka, Pavel; Radice, Paolo; Peterlongo, Paolo; EPICOLON Consortium (Public Library Science, 2014-01)
The common 2652 6N del variant in the CASP8 promoter (rs3834129) has been described as a putative low-penetrance risk factor for different cancer types. In particular, some studies suggested that the deleted allele (del) ... -
Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex
; ; ; ; ; ; ; ; ; ; Alonso Gómez, Ángel María; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (MDPI, 2019-11-08)
Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals ... -
Beneficial effect of ursodeoxycholic acid in patients with acyl-CoA oxidase 2 (ACOX2) deficiency-associated hypertransaminasemia
; ; ; ; ; ; ; ; Bujanda Fernández de Pierola, Luis; ; ; ; ; ; ; ; ; ; ; ; ; ; (Wiley, 2022-11)
Background and Aims: A variant (p.Arg225Trp) of peroxisomal acyl-CoA oxidase 2 (ACOX2), involved in bile acid (BA) side-chain shortening, has been associated with unexplained persistent hypertransaminasemia and ... -
Brain connectivity and cognitive functioning in individuals six months after multiorgan failure
(Elsevier, 2019-12)Abstract Multiorgan failure (MOF) is a life-threating condition that affects two or more systems of organs not involved in the disorder that motivates admission to an Intensive Care Unit (ICU). Patients who survive MOF ... -
Broad Phenotypes of Disorders/Differences of Sex Development in MAMLD1 Patients Through Oligogenic Disease
Flueck, Christa E.; Audi, Laura; Fernández Cancio, Mónica; Sauter, Kay Sara; Martínez de la Piscina Martín, Idoia; Castaño González, Luis Antonio; Esteva, Isabel; Camats, Nuria (Frontiers Media, 2019-08-29)
Disorders/differences of sex development (DSD) are the result of a discordance between chromosomal, gonadal, and genital sex. DSD may be due to mutations in any of the genes involved in sex determination and development ... -
Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma
(Ferrata Storti Foundation, 2019-08-31)Burkitt-like lymphoma with 11q aberration is characterized by pathological features and gene expression profile resembling those of Burkitt lymphoma but lacks the MYC rearrangement and carries an 11q-arm aberration with ... -
Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Bañales Asurmendi, Jesús María; ; ; ; ; ; ; ; Andersen, Jesper B.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Springer Nature, 2020-06-30)
[EN] Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% ... -
Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Andersen, Jesper B.; ; ; Bujanda Fernández de Pierola, Luis; ; ; ; Bañales Asurmendi, Jesús María (Elsevier, 2022-05)
Background & Aims: Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence and related mortality is increasing. This study investigates the clinical course of CCA and subtypes (intrahepatic ... -
Citometría de flujo en el diagnóstico de los derrames neoplásicos.
(2022-02-25)La carcinomatosis peritoneal y el derrame pleural maligno son causas frecuentes de derrame. La citología es actualmente el gold estándar para el diagnóstico de los derrames malignos; pero posee una sensibilidad baja y un ... -
Clinical correlates of anti-SARS-CoV-2 antibody profiles in Spanish COVID-19 patients from a high incidence region
Markewitz, Robert; Torge, Antje; Wandinger, Klaus-Peter; Pauli, Daniela; Franke, Andre; Bujanda Fernández de Pierola, Luis; Marimón Ortiz de Zarate, José María; Bañales Asurmendi, Jesús María ; Gutiérrez Stampa, María Angeles; Nafría, Beatriz; Junker, Ralf (Nature, 2021-02-23)
Laboratory testing for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) consists of two pillars: the detection of viral RNA via rt-PCR as the diagnostic gold standard in acute cases, and the detection of ... -
Clinical features and outcomes of Streptococcus anginosus group infective Endocarditis: a multicenter matched cohort study
(Oxford University Press, 2021-03-29)[EN] Background. Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. Methods. ... -
Colorectal Cancer Genetic Variants Are Also Associated with Serrated Polyposis Syndrome Susceptibility
Arnau Collell, Coral; Soares de Lima, Yasmin; Díaz Gay, Marcos; Muñoz, Jenifer; Carballal, Sabela; Bonjoch, Laia; Moreira, Leticia; Lozano, Juan José; Ocaña, Teresa; Cuatrecasas, Miriam; Díaz de Bustamante, Aranzazu; Castells, Antoni; Capella, Gabriel; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Rodríguez Alcalde, Daniel; Balaguer, Francesc; Ruiz Ponte, Clara; Valle, Laura; Moreno, Víctor; Castellví Bel, Sergi (BMJ Publishing Group, 2020-10)
Background Serrated polyposis syndrome (SPS) is a clinical entity characterised by large and/ormultiple serrated polyps throughout the colon and increased risk for colorectal cancer (CRC). The basis for SPS genetic ... -
Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy
Murcia, Oscar; Juárez, Míriam; Rodríguez Soler, María; Hernández Illán, Eva; Giner Calabuig, Mar; Alustiza, Miren; Egoavil, Cecilia; Castillejo, Adela; Alenda, Cristina; Barberá, Víctor; Mangas Sanjuan, Carolina; Yuste, Ana; Bujanda Fernández de Pierola, Luis; Clofent, Joan; Andreu, Montserrat; Castells, Antoni; Llor, Xavier; Zapater, Pedro; Jover, Rodrigo (Public Library of Science, 2018-09-06)
Objective The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate ... -
Colorectal Cancer Survival in 50- to 69-Year-Olds after Introducing the Faecal Immunochemical Test
Gutierrez Stampa, María Angeles; Aguilar Gama, Vanessa; Sarasqueta Eizaguirre, Cristina; Cubiella, Joaquín; Portillo Villares, María Isabel; Bujanda Fernández de Pierola, Luis (MDPI, 2020-08-25)
Population screening has improved early diagnosis of colorectal cancer (CRC). Nonetheless, most cases are diagnosed in symptomatic patients. Faecal immunochemical testing has been recommended for assessing patients with ... -
Consumption of Caffeinated Beverages and Kidney Function Decline in an Elderly Mediterranean Population with Metabolic Syndrome
; ; ; ; ; ; ; ; Alonso Gómez, Ángel María; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Nature, 2021-03-31)
It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and ... -
Contribuciones al estudio de factores de riesgo y mortalidad del Delirium y fragilidad en adultos mayores hospitalizados.
(2022-09-27)Esta tesis se enmarca en un estudio observacional para el que se reclutaron 741 personas ingresadas en el Hospital Universitario de Álava que cumplían los requisitos de inclusión. Los miembros del equipo de investigación ... -
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
; ; ; ; ; ; ; ; Alonso Gómez, Ángel María; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Public Library Science, 2022-04-13)
BACKGROUND: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive ... -
Correlative super-resolution fluorescence and electron microscopy using conventional fluorescent proteins in vacuo
Peddie, Christopher J.; Domart, Marie-Charlotte; Snetkov, Xenia; O'Toole, Peter; Larijani, Banafshé; Way, Michael; Cox, Susan; Collinson, Lucy M. (Elsevier, 2017-08)
Super-resolution light microscopy, correlative light and electron microscopy, and volume electron microscopy are revolutionising the way in which biological samples are examined and understood. Here, we combine these ... -
Código GiTEP: optimización de la atención en pacientes con tromboembolismo pulmonar grave en el ámbito de Gipuzkoa desde una intervención multidisciplinar.
(2018-06-18)La enfermedad tromboembólica venosa y más concretamente el tromboembolismo pulmonar (TEP), representa una grave amenaza para la salud, convirtiéndose en la tercera enfermedad cardiovascular por su importancia epidemiológica ... -
Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy in KRAS Wild-Type Patients
Er, Tze-Kiong; Chen, Chih-Chieh; Bujanda Fernández de Pierola, Luis; Herreros Villanueva, Marta (Hindawi Publishing, 2014)
Targeting epidermal growth factor receptor (EGFR) has been one of the most effective colorectal cancer strategies. Anti-EGFR antibodies function by binding to the extracellular domain of EGFR, preventing its activation, ...