BackExaminar por departamento (eus.) "Farmakologia"
Now showing items 21-40 of 129
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Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers
Requejo Rodríguez, Catalina
; López de Ipiña Peña, Miren Karmele ; Ruiz Ortega, José Ángel ; Fernández Gómez de Segura, Elsa; Calvo Salomón, Pilar María; Morera Herreras, Teresa ; Miguélez Palomo, Cristina; Cardona Grifoll, Laura; Cepeda Berenguer, Hodei; Ugedo Urruela, Luisa ; Lafuente Sánchez, José Vicente (Frontiers Media, 2020-10-14)
The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ... -
Characterization of a double-hit mouse model of schizophrenia. Focus on inflammatory and epigenetic processes, pharmacological modulation and sex bias
Cordero Ruiz, Natalia (2023-02-17)
Los déficits cognitivos de la esquizofrenia son un síntoma central, son indicadores del pronóstico de la enfermedad y son resistentes a los tratamientos actuales. Se sospecha que los antipsicóticos atípicos podrían empeorar ... -
Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
Pérez del Palomar Asín, Blanca (2019-12-02)
Schizophrenia is a multi multifaceted, heterogeneous, chronic and debilitating disorder triggered by a series of interacting genetic, developmental and environmental factors. Cognitive impairment is considered a core feature ... -
Characterization of buspirone effect on output basal ganglia nuclei in 6-hydroxydopamine lesioned rats with and without long-term levodopa treatment.
Vegas Suárez, Sergio (2020-05-22)
La enfermad de Párkinson es un trastorno neurodegenerativo en el que varios sistemas de neurotransmisión se ven afectados. En los últimos años, numerosas evidencias clínicas y experimentales han demostrado el papel del ... -
Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia
; ; ; ; Callado Hernando, Luis Felipe; Meana Martínez, José Javier ; Díez Alarcia, Rebeca (Springer, 2021-08)
Background: Alterations of dopamine D-1 (D1R) and D-2 receptor (D2R) are proposed in schizophrenia but brain neuroimaging and postmortem studies have shown controversial results in relation to D1R and D2R density. Besides, ... -
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Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
Fernández Fernández, Cristina; Callado Hernando, Luis Felipe; Girón, Rocío; Sánchez, Eva; Erdozain Fernández, Amaia Maite ; López-Moreno, José Antonio; Morales, Paula; Rodríguez de Fonseca, Fernando; Fernández-Ruiz, Javier; Goya, Pilar; Meana Martínez, José Javier ; Martín, Isabel; Jagerovic, Nadine (Dove Medical Press, 2014)
Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared ... -
Constitutive activity and drug functional selectivity of 5-HT2A receptors in post-mortem brain of subjects with schizophrenia
Muneta Arrate, Itziar (2022-07-12)
La esquizofrenia es una enfermedad mental crónica e incapacitante de etiología aún desconocida. El receptor 2A de serotonina (5-HT2AR) es a la vez diana de compuestos alucinógenos y de antipsicóticos atípicos. Los estudios ... -
Current Techniques for Investigating the Brain Extracellular Space
Soria Lannes, Federico Nicolás; ; Peñagarikano Ahedo, Olga ; Tonnesen, Jan (Frontiers Media, 2020-10-14)
The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions ... -
Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain
Gil de la Pisa, Itziar; Cebrián, Carolina; Ortega Calvo, Jorge; Meana Martínez, José Javier; Sulzer, David (Biomed Central, 2014-07-29)
Background: An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be ... -
D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus
(Nature Publishing, 2018-06-11)Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement ... -
Decreased Striatal Adenosine A(2A)-Dopamine D(2)Receptor Heteromerization in Schizophrenia
Valle León, Marta; Callado Hernando, Luis Felipe; Aso, Ester; Cajiao Manrique, María del Mar; Sahlholm, Kristoffer; López Cano, Marc; Soler, Concepcio; Altafaj, Xavier; Watanabe, Masahiko; Ferre, Sergi; Fernández Dueñas, Víctor; Menchón, José Manuel; Ciruela, Francisco (Springer Nature, 2020-10-03)
According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of the adenosinergic system. Such a hypoadenosinergic state might either be ... -
Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA
; ; Llamosas Muñozguren, Nerea; ; (Cell Press, 2015-08-11)
Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson's disease (PD) and psychiatric disorders. L-DOPA, the leading treatment of PD, facilitates ... -
Desarrollo de técnicas farmacológicas para la identificación y cribado de fármacos mediante microarrays de membranas celulares
(2016-07-15)Los microarrays de membranas celulares han sido desarrollados como una herramienta farmacológica que permite el estudio tanto de la densidad como de la funcionalidad de las proteínas de membrana en diferentes tejidos o ... -
Desarrollo de un sistema de genotipado para la aplicación en el "trastorno por déficit de atención con hiperactividad" y su farmacogenética
(2014-02-24)El trastorno por déficit de atención con hiperactividad (TDAH) es el trastorno neuropsiquiátrico más común en la infancia, con una prevalencia del 8 al 12% entre la población infanto-juvenil en todo el mundo, de los cuales ... -
Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell membranes: an alternative to radioligand binding methods
; ; Echeazarra Escudero, Leire; ; Barrondo Lacarra, Sergio ; López de Jesús, Maider ; González Burguera, Imanol ; ; Goicolea Altuna, María Aranzazu ; Sallés Alvira, Joan ; (BMC, 2022)
Background: Replacement of radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels requires the use of purified protein standards ... -
Determining the binding kinetics and signalling effects of CB1 and CB2 receptor ligands; a closer look at residence time and functional selectivity
(2022-05-30)The CB1 and CB2 receptors are the main GPCRs of the endocannabinoid system, and regulate many important physiological processed as pain, inflammation, or behaviour. Increasing interest exist to develop new drugs targeting ... -
Di-aryl guanidinium derivatives: Towards improved α2-Adrenergic affinity and antagonist activity
McMullan, Michela; Kelly, Brendan; Mihigo, Helene B.; Keogh, Aaron P.; Rodríguez, Fernando; Brocos Mosquera, Iria; García Bea, Aintzane; Miranda Azpiazu, Patricia; Callado Hernando, Luis Felipe; Rozas, Isabel (Elsevier, 2021-01-01)
Compounds with excellent receptor engagement displaying alpha(2)-AR antagonist activity are useful not only for therapeutic purposes (e.g. antidepressants), but also to help in the crystallization of this particular GPCR. ... -
Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment
; ; Muguruza Millán, Carolina; ; ; Meana Martínez, José Javier ; Callado Hernando, Luis Felipe ; Rivero Calera, Guadalupe (Springer Nature, 2021-12-20)
[EN] Postsynaptic alpha(2A)-adrenoceptor density is enhanced in the dorsolateral prefrontal cortex (DLPFC) of antipsychotic-treated schizophrenia subjects. This alteration might be due to transcriptional activation, and ... -
Dopamine D4 Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum
(MDPI, 2021-12-23)Long-term exposition to morphine elicits structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, morphine-induced neuroadaptations in the dorsal striatum ...