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Now showing items 18919-18938 of 37834
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In vitro characterization of LDLR, PCSK9 and APOB variants as a tool to understand molecular aspects of familial hypercholesterolemia and improving genetic diagnosis.
(2018-12-19)La hipercolesterolemia familiar es una enfermedad genética autosómica dominante que se caracteriza por unos niveles altos de colesterol en plasma. Este colesterol, con el tiempo se acumula en las paredes vasculares y ... -
In Vitro Degradation of PLCL/nHA Biodegradable Scaffolds
; Puerto Lecanda, Igor
(Taylor & Francis, 2015-04-01)
We investigated the effect of bioactive nanoparticles on the in-vitro degradation of PLCL and PLCL/nHA composite scaffolds. The concentration of nanohydroxyapatite significantly affected the degradation rate. An increase ... -
In Vitro Degradation of PLLA/nHA Composite Scaffolds
; ; Puerto Lecanda, Igor; Ibáñez Fernández, María del Mar (Wiley, 2013-11-08)
Porous Poly-L-lactide (PLLA) scaffolds and PLLA/nanohydroxyapatite (nHA) composite scaffolds with interconnected pore networks and a porosity of over 90% were fabricated with lyophilization techniques. In this study, ... -
In Vitro Degradation of Poly(caprolactone)/nHA Composites
(Hindawi Publishing, 2014)The degradation behavior and mechanical properties of polycaprolactone/nanohydroxyapatite composite scaffolds are studied in phosphate buffered solution (PBS), at 37 degrees C, over 16 weeks. Under scanning electron ... -
In vitro ernalketaren eragina haurdunaldiko eritasun hipertentsiboan : berrikuspen bibliografikoa
(2021-12-22)[EUS] In vitro ernalketa (IVE) ugalketa lagundurako teknika arrakastatsuena da gaur egun. Azken urteetan bere erabilera biderkatzearekin batera, teknika honen inguruko ikerketa gehiago argitaratu dira; hala nola, IVE-k ... -
In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris
Caballero Cuenca, Unai; Eraso Barrio, María Elena; ; Jauregizar Albonigamayor, Nerea (MDPI, 2021-08-25)
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated. The aim ... -
In Vitro P38MAPK Inhibition in Aged Astrocytes Decreases Reactive Astrocytes, Inflammation and Increases Nutritive Capacity After Oxygen-Glucose Deprivation
Revuelta Aramberri, Miren; Elicegui Aguirre, Amaia; Scheuer, Till; Endesfelder, Stefanie; Buehrer, Christoph; Moreno Cugnon, Leire; Matheu Fernández, Ander; Schmitz, Thomas (Impact Journals LLC, 2021-03-15)
Proper astroglial functioning is essential for the development and survival of neurons and oligodendroglia under physiologic and pathological circumstances. Indeed, malfunctioning of astrocytes represents an important ... -
In vitro pharmacodynamic modelling of anidulafungin against Candida spp.
Gil Alonso, Sandra; Jauregizar Albonigamayor, Nerea ; ; Eraso Barrio, María Elena ; ; (Elsevier, 2016-03)
[ES] El objetivo de este estudio fue ajustar los datos estáticos de muerte temporal in vitro de anidulafungina de nueve cepas de Candida con un modelo farmacodinámico (PD) para describir la actividad antifúngica de este ... -
In Vitro Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Amphotericin B against Candida auris
Caballero Cuenca, Unai; Eraso Barrio, María Elena; Pemán, Javier; ; Vozmediano, Valvanera; Schmidt, Stephan; Jauregizar Albonigamayor, Nerea (MDPI, 2021-10-22)
The aims of this study were to characterize the antifungal activity of amphotericin B against Candida auris in a static in vitro system and to evaluate different dosing schedules and MIC scenarios by means of semi-mechanistic ... -
In vitro Production of Hemin-Based Artificial Metalloenzymes
; ; ; ; López Cortajarena, Aitziber (Wiley, 2024-02)
Developing enzyme alternatives is pivotal to improving and enabling new processes in biotechnology and industry. Artificial metalloenzymes (ArMs) are combinations of protein scaffolds with metal elements, such as metal ... -
In Vitro Screening and Lipid-Lowering Effect of Prickly Pear (Opuntia Ficus-Indica L. Mill.) Fruit Extracts in 3T3-L1 Pre-Adipocytes and Mature Adipocytes
(Springer Nature, 2024)Opuntia ficus-indica fruits have been widely used due to their nutritional composition and beneficial effects on health, particularly against chronic diseases such as diabetes, obesity, cardiovascular diseases and cancer, ... -
In Vitro Surfactant and Perfluorocarbon Aerosol Deposition in a Neonatal Physical Model of the Upper Conducting Airways
Goikoetxea, Estibalitz; Murgia, Xabier; Serna-Grande, Pablo; Valls Soler, Adolfo; Rey Santano, María Carmen; Rivas, Alejandro; Antón, Raúl; Basterrechea Elguezabal, Francisco José; Miñambres Durán, Lorena; Méndez Alija, Estíbaliz; López Arraiza, Alberto ; Larrabe Barrena, Juan Luis ; Gómez Solaeche, Miguel Ángel (Public Library Science, 2014-09-11)
Objective: Aerosol delivery holds potential to release surfactant or perfluorocarbon (PFC) to the lungs of neonates with respiratory distress syndrome with minimal airway manipulation. Nevertheless, lung deposition in ... -
In Vitro Synergistic Interactions of Isavuconazole and Echinocandins against Candida auris
Caballero Cuenca, Unai; Kim, Sarah; Eraso Barrio, María Elena; ; Vozmediano, Valvanera; Schmidt, Stephan; Jauregizar Albonigamayor, Nerea (MDPI, 2021-03-28)
Candida auris is an emergent fungal pathogen that causes severe infectious outbreaks globally. The public health concern when dealing with this pathogen is mainly due to reduced susceptibility to current antifungal drugs. ... -
In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model
Azkona Mendoza, Garikoitz; ; ; (Springer, 2010-07-02)
Down syndrome, the most common genetic disorder leading to mental retardation, is caused by the presence of all or part of an extra copy of chromosome 21. At relatively early ages, Down syndrome patients develop progressive ... -
In vivo functional role of the 5-HT2A/mGlu2 receptor heterocomplex in rodents
(2018-01-11)La esquizofrenia es una enfermedad prototípica humana de etiología aún desconocida. La investigación con modelos animales permite estudiar las causas y mecanismos afectados en dicha enfermedad. Así, fármacos como el DOI, ... -
In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke
Joya, Ana; Ardaya Franco, María Isabel; Montilla López, Alejandro; Garbizu, Maider; Plaza García, Sandra; Gómez Vallejo, Vanessa; Padró, Daniel; Gutiérrez Martín, Juan José; Ríos, Xabier; Ramos Cabrer, Pedro; Cossío Arrieta, Unai; Pulagam, Krishna Reddy; Higuchi, Makoto; Domercq García, María ; Cavaliere, Fabio; ; Llop Roig, Jordi ; Martín Muñoz, Abraham (Ivyspring International Publisher, 2021)
Adenosine A(l) receptors (A(l)ARs) are promising imaging biomarkers and targets for the treatment of stroke. Nevertheless, the role of A(l)ARs on ischemic damage and its subsequent neuroinflammatory response has been ... -
In vivo multimodal imaging of adenosine A2A receptors after experimental stroke
(2021-12-03)[EN] Ischemic stroke is an acute cerebrovascular disease characterised by a cascade of pathological events including excitotoxicity, inflammation and cellular death. Ischemia also leads to an increase of the concentrations ... -
In vivo PET Imaging of Gliogenesis After Cerebral Ischemia in Rats
Ardaya Franco, María Isabel; Joya, Ana; Padró, Daniel; Plaza García, Sandra; Gómez Vallejo, Vanessa; Sánchez, Mercedes; Garbizu, Maider; Cossío Arrieta, Unai; ; Cavaliere, Fabio; Llop Roig, Jordi; Martín Muñoz, Abraham (Frontiers Media, 2020-07-30)
In vivopositron emission tomography of neuroinflammation has mainly focused on the evaluation of glial cell activation using radiolabeled ligands. However, the non-invasive imaging of neuroinflammatory cell proliferation ... -
In vivo strategies for the study of ubiquitination and ubiquitin-related diseases: application to Angelman syndrome
Ramírez Sánchez, Juan Manuel (2016-10-17)
Ubikuitilazioa neuronen garapenerako eta funtzionamendurako ezinbesteko da. Neuronetan ubikuitina itsatsita daukaten proteinen identifikazioak asko lagunduko luke prozesu honek garunean dituen zereginak hobeto ulertzeko. ... -
`In Wellbeing we Trust'. Factores culturales estructurales y psicosociales del bienestar
(2016-04-21)Esta tesis fue construida bajo la premisa que el Bienestar de las personas tiene como fuente y se expresa a distintos niveles del quehacer humano, y se relaciona con distintos factores de acuerdo a estos niveles. El bienestar ...