Browsing by Author "Sáenz Cuesta, Matías"
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Aplicación clínica de las vesículas extracelulares en la esclerosis múltiple
Sáenz Cuesta, Matías (2015-12-18)En esta tesis se ha investigado la biología de las vesículas extracelulares en relación a la esclerosis múltiple, una enfermedad del sistema nervioso central, desmielinizante y con un claro componente autoinmune como ... -
Blood miRNA expression pattern is a possible risk marker for natalizumab-associated progressive multifocal leukoencephalopathy in multiple sclerosis patients
Muñoz Culla, Maider; Irizar, Haritz; Castillo Triviño, Tamara; Sáenz Cuesta, Matías; Sepúlveda, Lucía; Lopetegi, Itziar; López de Munain Arregui, Adolfo José; Olascoaga, Javier; Baranzini, Sergio; Otaegui Bichot, David (Sage, 2014-05-22)Background: Natalizumab has shown its efficacy in reducing multiple sclerosis (MS) relapses and progression of disability; however, it has been associated with an increased risk of developing progressive multifocal ... -
Identification of ncRNAs as Potential Therapeutic Targets in Multiple Sclerosis Through Differential ncRNA – mRNA Network Analysis
Irizar, Haritz; Muñoz Culla, Maider; Sáenz Cuesta, Matías; Osorio Querejeta, Iñaki; Sepúlveda, Lucía; Castillo Triviño, Tamara; Prada, Alvaro; López de Munain Arregui, Adolfo José; Olascoaga, Javier; Otaegui Bichot, David (Biomed Central, 2015-03-28)Background: Several studies have revealed a potential role for both small nucleolar RNAs (snoRNAs) and microRNAs (miRNAs) in the physiopathology of relapsing-remitting multiple sclerosis (RRMS). This potential implication ... -
Transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression
Irizar, Haritz; Muñoz Culla, Maider; Sepúlveda, Lucía; Sáenz Cuesta, Matías; Prada, Alvaro; Castillo Triviño, Tamara; Zamora López, Gorka; López de Munain Arregui, Adolfo José; Olascoaga, Javier; Otaegui Bichot, David (Public Library Science, 2014-02-28)Background: Although the most common clinical presentation of multiple sclerosis (MS) is the so called Relapsing-Remitting MS (RRMS), the molecular mechanisms responsible for its progression are currently unknown. To tackle ... -
Yerba mate (Ilex paraguariensis) inhibits lymphocyte activation in vitro
Muñoz-Culla, Maider; Sáenz Cuesta, Matías; Guereca-Barandiaran, Maier Juana; Ribeiro, Marcelo L.; Otaegui Bichot, David (Royal Society of Chemistry (RSC), 2016-09-19)Yerba mate (YM) has been shown to have anti-inflammatory properties in several studies. However, this effect has been found mainly in obesity-related inflammation. The aim of this work was to study the effect of YM on ...