Now showing items 1-20 of 183

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      A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold 

      Rendón Ramírez, Adela; Shukla, Manish; Oda, Masataka; Chakraborty, Sandeep; Minda, Renu; Dandekar, Abhaya M.; Asgeirsson, Bjarni; Goñi Urcelay, Félix María; Rao, Basuthkar J. (Public Library Science, 2013-08)
      Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous ...
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      A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene 

      Ibarrola Villava, Maider; Fernandez, Lara P.; Alonso Alegre, Santos; Boyano López, María Dolores; Peña Chilet, María; Pita, Guillermo; Avilés, José A.; Mayor, Matias; Gómez Fernández, Cristina; Casado, Beatriz; Martín González, Manuel; Izagirre Arribalzaga, Neskuts; De la Rúa Vaca, Concepción; Asumendi Mallea, Aintzane; Pérez-Yarza Pérez-Irezabal, Gorka; Arroyo Berdugo, Yoana; Boldo, Enrique; Lozoya, Rafael; Torrijos Aguilar, Arantxa; Pitarch, Ana; Pitarch, Gerard; Sánchez Motilla, José M.; Valcuende Cavero, Francisca; Tomás Cabedo, Gloria; Pérez Pastor, Gemma; Díaz Pérez, José Luis; Gardeazabal García, Jesús; Martínez de Lizarduy, Iñigo; Sánchez Diez, Ana; Valdés, Carlos; Pizarro, Angel; Casado, Mariano; Carretero, Gregorio; Botella Estrada, Rafael; Nagore, Eduardo; Lázaro, Pablo; Lluch, Ana; Benítez, Javier; Martínez Cadenas, Conrado; Ribas, Gloria (Public Library of Science, 2011-04-29)
      As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ...
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      A Delphi Process to Optimize Quality and Performance of Drug Evaluation in Neonates 

      Legrand, Frederic; Boulkedid, Rym; Elie, Valery; Leroux, Stephanie; Valls, Elizabeth; Valls Soler, Adolfo; Van den Anker, Johannes N.; Jacqz-Aigrain, Evelyne (Public Library Science, 2014-09-11)
      Background: Neonatal trials remain difficult to conduct for several reasons: in particular the need for study sites to have an existing infrastructure in place, with trained investigators and validated quality procedures ...
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      A Featureless Approach to 3D Polyhedral Building Modeling from Aerial Images 

      Hammoudi, Karim; Dornaika, Fadi (MDPI, 2011)
      This paper presents a model-based approach for reconstructing 3D polyhedral building models from aerial images. The proposed approach exploits some geometric and photometric properties resulting from the perspective ...
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      A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer 

      Antelo, Marina; Balaguer, Francesc; Shia, Jinru; Shen, Yan; Hur, Keun; Moreira, Leticia; Cuatrecasas, Miriam; Bujanda Fernández de Pierola, Luis; Giraldez, María Dolores; Takahashi, Masanobu; Cabanne, Ana; Barugel, Mario Edmund; Arnold, Mildred; Roca, Enrique Luis; Andreu, Montserrat; Castellvi-Bel, Sergi; Llor, Xavier; Jover, Rodrigo; Castells, Antoni; Boland, C. Richard; Goel, Ajay (Public Library of Science, 2012-09-25)
      Objective: Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized ...
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      A Model of Ischemia-Induced Neuroblast Activation in the Adult Subventricular Zone 

      Vergni, Davide; Castiglione, Filippo; Briani, Maya; Middei, Silvia; Alberdi Alfonso, Elena María; Reymann, Klaus G.; Natalini, Roberto; Volonté, Cinzia; Matute Almau, Carlos José; Cavaliere, Fabio (Public Library of Science, 2009-04-23)
      We have developed a rat brain organotypic culture model, in which tissue slices contain cortex-subventricular zone-striatum regions, to model neuroblast activity in response to in vitro ischemia. Neuroblast activation has ...
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      A Novel Micro- and Nano-Scale Positioning Sensor Based on Radio Frequency Resonant Cavities 

      Asua Uriarte, Estibaliz; Echevarría Ecenarro, Víctor; García Arribas, Alfredo; Feutchwanger Morales, Jorge; Portilla Rubin, Joaquín; Lucas, Julio (MDPI, 2014-06)
      In many micro- and nano-scale technological applications high sensitivity displacement sensors are needed, especially in ultraprecision metrology and manufacturing. In this work a new way of sensing displacement based on ...
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      A Self-Referencing Intensity Based Polymer Optical Fiber Sensor for Liquid Detection 

      Sánchez Montero, David; Vázquez, Carmen; Möllers, Ingo; Arrue Aramburu, Juan Antonio; Jäger, Dieter (MDPI, 2009-08)
      A novel self-referencing fiber optic intensity sensor based on bending losses of a partially polished polymer optical fiber (POF) coupler is presented. The coupling ratio (K) depends on the external liquid in which the ...
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      A Temperature Sensor Based on a Polymer Optical Fiber Macro-Bend 

      Tapetado Moraleda, Alberto; Vázquez García, Carmen; Zubia Zaballa, Joseba Andoni; Arrue Aramburu, Juan Antonio (MDPI, 2013-10)
      The design and development of a plastic optical fiber (POF) macrobend temperature sensor is presented. The sensor has a linear response versus temperature at a fixed bend radius, with a sensitivity of 1.92.10(-3) (degrees ...
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      A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation 

      Di Penta, Alessandra; Chiba, Asako; Alloza Moral, Iraide; Wyssenbach Ibarra, Ane; Yamamura, Takashi; Villoslada, Pablo; Miyake, Sachiko; Vandenbroeck, Koen (Public Library of Science, 2013-12-11)
      Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving ...
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      Accuracy in Copy Number Calling by qPCR and PRT : A Matter of DNA 

      Fernández-Jiménez, Nora; Castellanos Rubio, Ainara; Plaza-Izurieta, Leticia; Gutiérrez, Galder; Irastorza Terradillos, Iñaki Xarles; Castaño González, Luis Antonio; Vitoria Cormenzana, Juan Carlos; Bilbao Catalá, José Ramón (Public Library of Science, 2011-12-13)
      The possible implication of copy number variation (CNV) in the genetic susceptibility to human disease needs to be assessed using robust methods that can be applied at a population scale. In this report, we analyze the ...
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      Adenylate Cyclase Toxin Promotes Internalisation of Integrins and Raft Components and Decreases Macrophage Adhesion Capacity 

      Martín Plágaro, César Augusto; Uribe, Kepa B.; Gómez Bilbao, Geraxane; Ostolaza Echabe, Elena Amaya (Public Library of Science, 2011-02-23)
      Bordetella pertussis, the bacterium that causes whooping cough, secretes an adenylate cyclase toxin (ACT) that must be post-translationally palmitoylated in the bacterium cytosol to be active. The toxin targets phagocytes ...
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      Advantages and Versatility of Fluorescence-Based Methodology to Characterize the Functionality of LDLR and Class Mutation Assignment 

      Echevarria Gallego, Aitor; Benito Vicente, Asier; Ostolaza Echabe, Elena Amaya; Martín Plágaro, César Augusto (Public Library Science, 2014-11-11)
      Familial hypercholesterolemia (FH) is a common autosomal codominant disease with a frequency of 1:500 individuals in its heterozygous form. The genetic basis of FH is most commonly mutations within the LDLR gene. Assessing ...
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      Alcohol-Related Brain Damage in Humans 

      Erdozain Fernández, Amaia Maite; Morentin, Benito; Bedford, Lynn; King, Emma; Tooth, David; Brewer, Charlotte; Wayne, Declan; Johnson, Laura; Gerdes, Henry K.; Wigmore, Peter; Callado Hernando, Luis Felipe; Carter, Wayne G. (Public Library Science, 2014-04-03)
      Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control ...
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      An Embedded Stress Sensor for Concrete SHM Based on Amorphous Ferromagnetic Microwires 

      Olivera, Jesús; González, Margarita; Fuente, José Vicente; Varga, Rastislav; Zhukov, Arkady; Anaya, José Javier (MDPI, 2014-11)
      A new smart concrete aggregate design as a candidate for applications in structural health monitoring (SHM) of critical elements in civil infrastructure is proposed. The cement-based stress/strain sensor was developed by ...
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      An Optical Fiber Bundle Sensor for Tip Clearance and Tip Timing Measurements in a Turbine Rig 

      García, Iker; Beloki, Josu; Zubia Zaballa, Joseba Andoni; Aldabaldetreku Etxeberria, Gotzon; Illarramendi Leturia, María Asunción; Jiménez Hernández, Felipe (MDPI, 2013-06)
      When it comes to measuring blade-tip clearance or blade-tip timing in turbines, reflective intensity-modulated optical fiber sensors overcome several traditional limitations of capacitive, inductive or discharging probe ...
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      Ancient DNA from Hunter-Gatherer and Farmer Groups from Northern Spain Supports a Random Dispersion Model for the Neolithic Expansion into Europe 

      Hervella Afonso, Montserrat; Izagirre Arribalzaga, Neskuts; Alonso Alegre, Santos; Fregel, Rosa; Alonso, Antonio; Cabrera, Vicente M.; De la Rúa Vaca, Concepción (Public Library of Science, 2012-04-25)
      Background/Principal Findings: The phenomenon of Neolithisation refers to the transition of prehistoric populations from a hunter-gatherer to an agro-pastoralist lifestyle. Traditionally, the spread of an agro-pastoralist ...
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      Ancient DNA from South-East Europe Reveals Different Events during Early and Middle Neolithic Influencing the European Genetic Heritage 

      Hervella Afonso, Montserrat; Rotea, Mihai; Izagirre Arribalzaga, Neskuts; Constantinescu, Mihai; Alonso Alegre, Santos; Ioana, Mihai; Lazăr, Cătălin; Ridiche, Florin; Soficaru, Andrei Dorian; Netea, Mihai G.; De la Rúa Vaca, Concepción (Public Library Science, 2015-06-08)
      The importance of the process of Neolithization for the genetic make-up of European populations has been hotly debated, with shifting hypotheses from a demic diffusion (DD) to a cultural diffusion (CD) model. In this regard, ...
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      Antibody Complementarity-Determining Regions (CDRs) Can Display Differential Antimicrobial, Antiviral and Antitumor Activities 

      Polonelli, Luciano; Pontón, José; Elguezabal Vega, Natalia María; Moragues Tosantos, María Dolores; Casoli, Claudio; Pilotti, Elisabetta; Ronzi, Paola; Dobroff, Andrey S.; Rodrigues, Elaine G.; Juliano, Maria A.; Maffei, Domenico Leonardo; Magliani, Walter; Conti, Stefania; Travassos, Luiz R. (Public Library of Science, 2008-06-11)
      Background: Complementarity-determining regions (CDRs) are immunoglobulin (Ig) hypervariable domains that determine specific antibody (Ab) binding. We have shown that synthetic CDR-related peptides and many decapeptides ...
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      Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity 

      Orzáez, Mar; Sancho, Mónica; Marchán, Sandra; Mondragón, Laura; Montava, Rebeca; García Valero, Juan; Landeta Díaz, Olatz; Basañez, Gorka; Carbajo, Rodrigo J.; Pineda-Lucena, Antonio; Bujons, Jordi; Moure, Alejandra; Messeguer, Angel; Lagunas, Carmen; Herrero, Carmen; Pérez- Payá, Enrique (Public Library Science, 2014-10-20)
      Background: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although ...