Browsing by Author "Battaglia, Luigi"
Now showing items 1-3 of 3
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Gene delivery in the cornea: in vitro and ex vivo evaluation of solid lipid nanoparticle-based vectors
Vicente Pascual, Mónica; Albano, Andrea; Solinís Aspiazu, María Ángeles ; Serpe, Loredana; Rodríguez Gascón, Alicia; Foglietta, Loredana; Muntoni, Elisabetta; Torrecilla, Josune; Del Pozo Rodríguez, Ana ; Battaglia, Luigi (Future Medicine, 2018-08-01)Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for interleukin-10 (p- IL10) will allow the sustained de novo synthesis of the ... -
mRNA-Based Nanomedicinal Products to Address Corneal Inflammation by Interleukin-10 Supplementation
Gómez Aguado, Itziar ; Rodríguez Castejón, Julen ; Beraza Millor, Marina ; Vicente Pascual, Mónica; Rodríguez Gascón, Alicia; Garelli, Sara; Battaglia, Luigi; Del Pozo Rodríguez, Ana ; Solinís Aspiazu, María Ángeles (MDPI, 2021-09-15)The anti-inflammatory cytokine Interleukin-10 (IL-10) is considered an efficient treatment for corneal inflammation, in spite of its short half-life and poor eye bioavailability. In the present work, mRNA-based nanomedicinal ... -
Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production
Vicente Pascual, Mónica; Gómez Aguado, Itziar ; Rodríguez Castejón, Julen ; Rodríguez Gascón, Alicia; Muntoni, Elisabetta; Battaglia, Luigi; Del Pozo Rodríguez, Ana ; Solinís Aspiazu, María Ángeles (MDPI, 2020-06-23)One of the main challenges in gene therapy is the issue of delivery, and it is especially relevant for the success of gene therapy in the cornea. In the present work, eye drops containing biocompatible non-viral vectors ...