Browsing by Author "Munarriz Cuezva, Eva"
Now showing items 1-6 of 6
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Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia
Urigüen Echeverría, Leyre ; Gil Pisa, I.; Munarriz Cuezva, Eva; Berrocoso, E.; Pascau, J.; Soto Montenegro, María Luisa; Gutiérrez Adán, A.; Pintado, B.; Madrigal, J. L. M.; Castro, E.; Sánchez Blázquez, P.; Ortega, J. E.; Guerrero, M. J.; Ferrer Alcon, M.; García Sevilla, J. A.; Mico, J. A.; Desco, M.; Leza, Juan Carlos; Pazos, A.; Garzon, J.; Meana Martínez, José Javier (Nature Publishing Group, 2013-01)Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter ... -
Behavioural Evaluation of a Translational Animal Model of Schizophrenia
Cordero Ruiz, Natalia ; Muguruza Millán, Carolina ; Pérez del Palomar Asín, Blanca ; Munarriz Cuezva, Eva; Meana Martínez, José Javier ; Ortega Calvo, Jorge (Wiley, 2018-08)Schizophrenia (SZ) is a chronic and disabling psychiatric disorder affecting about 1% of the population worldwide. Schizophrenia comprises positive and negative symptoms as well as cognitive deficits. Epidemiological and ... -
Caracterización de las proteínas del complejo SNARE en esquizofrenia y su tratamiento
Munarriz Cuezva, Eva (2015-11-19)La esquizofrenia es una enfermedad de base biológica cuyo sustrato es poco conocido. A partir de un estudio de proteómica comparativa realizados en cerebro postmortem de individuos con esquizofrenia y individuos control ... -
Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia
Egusquiza, Iker; Munarriz Cuezva, Eva; Segarra Echevarria, Rafael; González Maeso, Javier; Callado Hernando, Luis Felipe ; Meana Martínez, José Javier ; Díez Alarcia, Rebeca (Springer, 2021-08)Background: Alterations of dopamine D-1 (D1R) and D-2 receptor (D2R) are proposed in schizophrenia but brain neuroimaging and postmortem studies have shown controversial results in relation to D1R and D2R density. Besides, ... -
Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia
Vila, Èlia; Pinacho, Raquel; Prades, Roger; Tarragó, Teresa; Castro, Elena; Munarriz Cuezva, Eva; Meana Martínez, José Javier ; Eugui Anta, Ania; Roldan, Mònica; Vera Montecinos, América; Ramos, Belén (MDPI, 2023-03-23)Cognitive impairment represents one of the core features of schizophrenia. Prolyl Oligopeptidase (POP) inhibition is an emerging strategy for compensating cognitive deficits in hypoglutamatergic states such as schizophrenia, ... -
Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
MacDowell, Karina S.; Munarriz Cuezva, Eva; Meana Martínez, José Javier ; Leza, Juan Carlos; Ortega Calvo, Jorge (Frontiers Media, 2021-05-13)Emerging evidence indicates that early-life exposure to environmental factors may increase the risk for schizophrenia via inflammatory mechanisms. Inflammation can alter the metabolism of tryptophan through the oxidative ...