Now showing items 1-2 of 2

    • Thumbnail

      Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results 

      Fernández Fernández, Cristina; Callado Hernando, Luis Felipe; Girón, Rocío; Sánchez, Eva; Erdozain Fernández, Amaia Maite; López-Moreno, José Antonio; Morales, Paula; Rodríguez de Fonseca, Fernando; Fernández-Ruiz, Javier; Goya, Pilar; Meana Martínez, José Javier; Martín, Isabel; Jagerovic, Nadine (Dove Medical Press, 2014)
      Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared ...
    • Thumbnail

      MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy 

      Umerez, Maitane; Gutiérrez Camino, Ángela; Muñoz Maldonado, Carmen; Martín Guerrero, Idoia; García-Orad Carles, África (Dove Medical Press, 2017-03-27)
      Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide ...