BackBrowsing by Author "Saenz de Urturi Indart, Diego"
Now showing items 1-8 of 8
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Atorvastatin Provides a New Lipidome Improving Early Regeneration After Partial Hepatectomy in Osteopontin Deficient Mice
; ; ; ; ; Buqué García, Xabier
; ; Martínez Chantar, María Luz ; ; ; (Nature Publishing Group, 2018-10-02)
Osteopontin (OPN), a multifunctional cytokine that controls liver glycerolipid metabolism, is involved in activation and proliferation of several liver cell types during regeneration, a condition of high metabolic demands. ... -
Efecto de la hipertermia sobre la proliferación de células CC531 in vitro
(2014-06-24)El cáncer colorrectal (CCR) es un problema mundial, con una incidencia anual de aproximadamente un millón de casos, y una mortalidad anual de más de 500.000. Así, el CCR es la segunda causa de mortalidad por cáncer entre ... -
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease
; ; ; ; Buqué García, Xabier; Aurrekoetxea Galindo, Igor ; ; ; ; ; ; ; ; ; Castaño González, Luis Antonio ; ; ; Martínez Chantar, María Luz ; ; (Wiley, 2020-07-07)
[EN] Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence has been associated with age-dependent hepatosteatosis. ... -
Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ... -
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
; Buqué García, Xabier; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Aurrekoetxea Galindo, Igor ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María ; ; ; Martínez Chantar, María Luz ; ; (Nature, 2022)
Altered methionine metabolism is associated with weight gain in obesity. The methionine adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an important role regulating lipid metabolism. ... -
Mineralocorticoid Receptor Modulation by Dietary Sodium Influences NAFLD Development in Mice
(Elsevier, 2021-04-30)Introduction and Objectives Nonalcoholic-fatty-liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Mineralocorticoid receptor (MR) activation is associated with increased risk of ... -
miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression
(MDPI, 2020-11-17)Insulin resistance (IR) is one of the key contributing factors in the development of type 2 diabetes mellitus (T2DM). However, the molecular mechanisms leading to IR are still unclear. The implication of microRNAs (miRNAs) ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ...