Browsing by Author "Van den Broek, Bram"
Now showing items 1-2 of 2
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Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation
Halim, Vincentius A.; García Santisteban, Iraia ; Warmerdam, Daniel O; Van den Broek, Bram; Heck, Albert J. R.; Mohammed, Shabaz; Medema, René H. (American Society for Biochemistry and Molecular Biology, 2018-12)Protein posttranslational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signaling cascade that coordinates ... -
Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells
García Santisteban, Iraia ; Llopis, Alba; Krenning, Lenno; Vallejo Rodríguez, Jon ; Van den Broek, Bram; Zubiaga Elordieta, Ana María ; Medem, René H. (BMC, 2021-02-19)BACKGROUND: The G1 checkpoint is a critical regulator of genomic stability in untransformed cells, preventing cell cycle progression after DNA damage. DNA double-strand breaks (DSBs) recruit and activate ATM, a kinase which ...