Now showing items 1-9 of 9

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      Atomistic Insights of Calmodulin Gating of Complete Ion Channels 

      Núñez, Eider; Muguruza Montero, Arantza; Villarroel Muñoz, Álvaro (MDPI, 2020-02-14)
      Intracellular calcium is essential for many physiological processes, from neuronal signaling and exocytosis to muscle contraction and bone formation. Ca<sup>2+</sup> signaling from the extracellular medium depends both on ...
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      Kv7 Channels Can Function without Constitutive Calmodulin Tethering 

      Gómez Posada, Juan Camilo; Aivar, Paloma; Alberdi González, Araitz; Alaimo Campi, Alessandro; Etxeberria, Ainhoa; Fernández-Orth, Juncal; Zamalloa Echevarría, Teresa; Roura-Ferrer, Meritxell; Villace Lozano, Patricia; Areso Goiricelaya, María Pilar; Casis Sáenz, Oscar; Villarroel Muñoz, Álvaro (Public Library of Science, 2011-09-28)
      M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 ...
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      Molecular determinants of Kv7.2 surface expression 

      Fernández Orth, Juncal (2014-02-25)
      El objetivo de esta tesis ha sido esclarecer las bases moleculares de la expresión en membrana de los canales M neuronales, crucial para una mejor comprensión de su funcionamiento. La densidad de canales en superficie se ...
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      Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex 

      Alaimo Campi, Alessandro; Alberdi González, Araitz; Gomis Pérez, Carolina; Fernández Orth, Juncal; Bernardo Seisdedos, Ganeko; Malo de la Fuente, Covadonga; Millet Aguilar-Galindo, Oscar; Areso Goiricelaya, María Pilar; Villarroel Muñoz, Álvaro (Public Library Science, 2014-01-28)
      Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, ...
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      Regulación del canal de potasio Kv7.2 por la calmodulina: estudio del conector de las hélices A y B en el dominio citoplasmático C-terminal 

      Bañales Belaunde, ïñigo (2020-01-16)
      [ES] Se estudia la potencial implicación del sitio de unión a PIP2 situado entre las hélices A y B del dominio C-terminal del canal de potasio Kv7.2 en el proceso de cambio conformacional mediado por la calmodulina.
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      Selective Interaction of Syntaxin 1A with KCNQ2: Possible Implications for Specific Modulation of Presynaptic Activity 

      Regev, Noa; Degani-Katzav, Nurit; Korngreen, Alon; Etzioni, Adi; Siloni, Sivan; Alaimo Campi, Alessandro; Chikvashvili, Dodo; Villarroel Muñoz, Álvaro; Attali, Bernard; Lotan, Ilana (Public Library Science,, 2009-08-13)
      KCNQ2/KCNQ3 channels are the molecular correlates of the neuronal M-channels, which play a major role in the control of neuronal excitability. Notably, they differ from homomeric KCNQ2 channels in their distribution pattern ...
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      Structural characterization of helices A and B of Kv7.2 channel bound to Calmodulin. The calcium effect 

      Bernardo Seisdedos, Ganeko (2015-12-15)
      Los canales neuronales heterodiméricos Kv7.2 y Kv7.3 son el sustrato molecular de la corriente depotasio no-inactivante dominada ¿Corriente M¿. Ésta juega un papel crítico en el control de laexcitabilidad neuronal. Su mal ...
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      Surface Expression and Subunit Specific Control of Steady Protein Levels by the Kv7.2 Helix A-B Linker 

      Aivar, Paloma; Fernández-Orth, Juncal; Gomis-Pérez, Carolina; Alberdi González, Araitz; Alaimo Campi, Alessandro; Rodríguez, Manuel S.; Giraldez, Teresa; Miranda, Pablo; Areso Goiricelaya, María Pilar; Villarroel Muñoz, Álvaro (Public Library of Science, 2013-10-24)
      Kv7.2 and Kv7.3 are the main components of the neuronal voltage-dependent M-current, which is a subthreshold potassium conductance that exerts an important control on neuronal excitability. Despite their predominantly ...
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      The Crossroad of Ion Channels and Calmodulin in Disease 

      Urrutia Iñiguez, Janire; Aguado Martínez, Alejandra; Muguruza Montero, Arantza; Núñez Viadero, Eider; Malo de la Fuente, Covadonga; Casis Sáenz, Oscar; Villarroel Muñoz, Álvaro (MDPI, 2019-01-02)
      Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major ...