IRAKASKUNTZA;;DOCENCIAhttp://hdl.handle.net/10810/12024-03-29T15:47:49Z2024-03-29T15:47:49ZAnti-Obesity Effect of Different Opuntia stricta var. dillenii’s Prickly Pear Tissues and Industrial By-Product Extracts in 3T3-L1 Mature AdipocytesGómez López, IvánEseberri Barace, ItziarCano, M. PilarPortillo Baquedano, María Puyhttp://hdl.handle.net/10810/665332024-03-28T05:56:15Z2024-02-09T00:00:00ZAnti-Obesity Effect of Different Opuntia stricta var. dillenii’s Prickly Pear Tissues and Industrial By-Product Extracts in 3T3-L1 Mature Adipocytes
Gómez López, Iván; Eseberri Barace, Itziar; Cano, M. Pilar; Portillo Baquedano, María Puy
Opuntia stricta var. dillenii fruit is a source of phytochemicals, such as betalains and phenolic compounds, which may play essential roles in health promotion. The aim of this research was to study the triglyceride-lowering effect of green extracts, obtained from Opuntia stricta var. dillenii fruit (whole fruit, pulp, peel, and industrial by-products (bagasse)) in 3T3-L1 mature adipocytes. The cells were treated on day 12, for 24 h, after the induction of differentiation with the extracts, at doses of 10, 25, 50, or 100 μg/mL. The expression of genes (PCR-RT) and proteins (Western blot) involved in fatty acid synthesis, fatty acid uptake, triglyceride assembly, and triglyceride mobilisation was determined. The fruit pulp extraction yielded the highest levels of betalains, whereas the peel displayed the greatest concentration of phenolic compounds. The extracts from whole fruit, peel and pulp were effective in reducing triglyceride accumulation at doses of 50 μg/mL or higher. Bagasse did not show this effect. The main mechanisms of action underpinning this outcome encompass a reduction in fatty acids synthesis (de novo lipogenesis), thus limiting their availability for triglyceride formation, alongside an increase in triglyceride mobilisation. However, their reliance is contingent upon the specific Opuntia extract.
2024-02-09T00:00:00ZClear Cell Renal Cell Carcinoma: A Test Bench for Investigating Tumor ComplexityManini, ClaudiaLópez Fernández, EstíbalizLarrinaga Embeita, GorkaLópez Fernández de Villaverde, José Ignaciohttp://hdl.handle.net/10810/665312024-03-28T05:50:04Z2024-02-19T00:00:00ZClear Cell Renal Cell Carcinoma: A Test Bench for Investigating Tumor Complexity
Manini, Claudia; López Fernández, Estíbaliz; Larrinaga Embeita, Gorka; López Fernández de Villaverde, José Ignacio
Clear cell renal cell carcinoma (CCRCC), by far the most common renal cancer subtype, is an aggressive tumor variant, serving in recent years as a prolific test bench in cancer research [...]
2024-02-19T00:00:00ZModelling and Measuring Trust in Human–Robot CollaborationLoizaga, ErlantzBastida, LeireSillaurren, SaraMoya, AnaToledo Gandarias, Nereahttp://hdl.handle.net/10810/665292024-03-28T05:08:39Z2024-02-26T00:00:00ZModelling and Measuring Trust in Human–Robot Collaboration
Loizaga, Erlantz; Bastida, Leire; Sillaurren, Sara; Moya, Ana; Toledo Gandarias, Nerea
Recognizing trust as a pivotal element for success within Human–Robot Collaboration (HRC) environments, this article examines its nature, exploring the different dimensions of trust, analysing the factors affecting each of them, and proposing alternatives for trust measurement. To do so, we designed an experimental procedure involving 50 participants interacting with a modified ‘Inspector game’ while we monitored their brain, electrodermal, respiratory, and ocular activities. This procedure allowed us to map dispositional (static individual baseline) and learned (dynamic, based on prior interactions) dimensions of trust, considering both demographic and psychophysiological aspects. Our findings challenge traditional assumptions regarding the dispositional dimension of trust and establish clear evidence that the first interactions are critical for the trust-building process and the temporal evolution of trust. By identifying more significant psychophysiological features for trust detection and underscoring the importance of individualized trust assessment, this research contributes to understanding the nature of trust in HRC. Such insights are crucial for enabling more seamless human–robot interaction in collaborative environments.
2024-02-26T00:00:00ZDiastereoselective ZnCl2-Mediated Joullié–Ugi Three-Component Reaction for the Preparation of Phosphorylated N-Acylaziridines from 2H-AzirinesAllende, JuleneOlaizola Alvarez, YurreOchoa de Retana Mendibil, Ana MaríaPalacios, FranciscoDe los Santos Ruiz, Jesús Manuelhttp://hdl.handle.net/10810/665272024-03-28T05:54:19Z2024-02-27T00:00:00ZDiastereoselective ZnCl2-Mediated Joullié–Ugi Three-Component Reaction for the Preparation of Phosphorylated N-Acylaziridines from 2H-Azirines
Allende, Julene; Olaizola Alvarez, Yurre; Ochoa de Retana Mendibil, Ana María; Palacios, Francisco; De los Santos Ruiz, Jesús Manuel
We disclose a direct approach to the diastereoselective synthesis of phosphorus substituted N-acylaziridines based on a one-pot ZnCl2-catalyzed Joullié–Ugi three-component reaction of phosphorylated 2H-azirines, carboxylic acids and isocyanides. Hence, this robust protocol offers rapid access to an array of N-acylaziridines in moderate-to-good yields and up to 98:2 dr for substrates over a wide scope. The relevance of this synthetic methodology was achieved via a gram-scale reaction and the further derivatization of the nitrogen-containing three-membered heterocycle. The diastereo- and regioselective ring expansion of the obtained N-acylaziridines to oxazole derivatives was accomplished in the presence of BF3·OEt2 as an efficient Lewid acid catalyst.
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