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      Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments 

      Rujas Díez, Edurne; Insausti González, Sara; Leaman, Daniel P.; Carravilla Palomanes, Pablo ORCID; González Resines, Saul; Monceaux, Valérie; Sánchez Eugenia, Rubén ORCID; García Porras, Miguel; Iloro, Ibon; Zhang, Lei; Elortza, Felix; Julien, Jean Philippe; Sáez Cirión, Asier; Zwick, Michael B.; Eggeling, Christian; Ojida, Akio; Domene, Carmen; Caaveiro, Jose M.M.; Nieva Escandón, José Luis (Cell Press, 2020-08-18)
      The contribution of membrane interfacial interactions to recognition of membrane-embedded antigens by antibodies is currently unclear. This report demonstrates the optimization of this type of antibodies via chemical ...
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      Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile 

      Rujas Díez, Edurne; Leaman, Daniel P.; Insausti González, Sara; Carravilla Palomanes, Pablo ORCID; García Porras, Miguel; Largo Pereda, Eneko; Morillo Melero, Izaskun; Sánchez Eugenia, Rubén ORCID; Zhang, Lei; Cui, Hong; Iloro, Ibon; Elortza, Felix; Julien, Jean-Philippe; Eggeling, Christian; Zwick, Michael B.; Caaveiro, Jose M.M.; Nieva Escandón, José Luis (Cell Press, 2021-09-24)
      Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the ...