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dc.contributor.authorDomercq García, María
dc.contributor.authorVázquez Villoldo, Nuria
dc.contributor.authorMatute Almau, Carlos José
dc.date.accessioned2014-01-24T18:06:08Z
dc.date.available2014-01-24T18:06:08Z
dc.date.issued2013
dc.identifier.citationFrontiers in Cellular Neuroscience 7 : (2013) // Article ID 49es
dc.identifier.issn1662-5102
dc.identifier.urihttp://hdl.handle.net/10810/11275
dc.descriptionErratun publicado en Frontiers in Cellular Neuroscience 7 : (2013) // Article ID 107es
dc.description.abstractMicroglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia are closely associated with astrocytes and neurons, particularly at the synapses, and more recent data indicate that neurotransmission plays a role in regulating the morphology and function of surveying/resting microglia, as they are endowed with receptors for most known neurotransmitters. In particular, microglia express receptors for ATP and glutamate, which regulate microglial motility. After local damage, the release of ATP induces microgliosis and activated microglial cells migrate to the site of injury, proliferate, and phagocytose cells, and cellular compartments. However, excessive activation of microglia could contribute to the progression of chronic neurodegenerative diseases, though the underlying mechanisms are still unclear. Microglia have the capacity to release a large number of substances that can be detrimental to the surrounding neurons, including glutamate, ATP, and reactive oxygen species. However, how altered neurotransmission following acute insults or chronic neurodegenerative conditions modulates microglial functions is still poorly understood. This review summarizes the relevant data regarding the role of neurotransmitter receptors in microglial physiology and pathology.es
dc.description.sponsorshipOur work is funded by Fundacion Mutua Madrilena, MINECO, ERANET-Neuron (Nanostroke), CIBERNED, Gobierno Vasco and Universidad del Pais Vasco. Nuria Vazquez-Villoldo holds a fellowship from Gobierno Vasco.es
dc.language.isoenges
dc.publisherFrontiers Research Foundationes
dc.relationinfo:eu-repo/grantAgreement/MINECO
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectmicrogliaes
dc.subjectATPes
dc.subjectglutamatees
dc.subjectpurinergic and glutamatergic receptorses
dc.titleNeurotransmitter signaling in the pathophysiology of microgliaes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder©2013 Domercq, Vázquez-Villoldo and Matute.This is an open-access article distributed under the termsof the CreativeCommonsAttribution License, whichpermitsuse,distribution and reproduction in other forums,provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc..es
dc.relation.publisherversionhttp://www.frontiersin.org/Journal/10.3389/fncel.2013.00049/fulles
dc.identifier.doi10.3389/fncel.2013.00049
dc.departamentoesNeurocienciases_ES
dc.departamentoeuNeurozientziakes_ES
dc.subject.categoriaCELLULAR AND MOLECULAR NEUROSCIENCE


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