Inter- and intramolecular enantioselective carbolithiation reactions
Gómez San Juan, Asier
Sotomayor Anduiza, María Nuria
Lete Expósito, María Esther
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Beilstein Journal of Organic Chemistry 9 : 313-322 (2013)
In this review we summarize recent developments in inter- and intramolecular enantioselective carbolithiation reactions carried out in the presence of a chiral ligand for lithium, such as (-)-sparteine, to promote facial selection on a C=C bond. This is an attractive approach for the construction of new carbon-carbon bonds in an asymmetric fashion, with the possibility of introducing further functionalization on the molecule by trapping the reactive organolithium intermediates with electrophiles.