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dc.contributor.authorCardoso Martín, Sergio
dc.contributor.authorValverde Potes, Laura
dc.contributor.authorAlfonso Sánchez, Miguel Ángel
dc.contributor.authorPalencia Madrid, Leire
dc.contributor.authorElcoroaristizabal Martín, Xabier
dc.contributor.authorAlgorta Pineda, Jaime
dc.contributor.authorCatarino, Susana
dc.contributor.authorArteta, David
dc.contributor.authorHerrera, Rene J.
dc.contributor.authorZarrabeitia, María Teresa
dc.contributor.authorPeña García, José Ángel
dc.contributor.authorMartínez de Pancorbo Gómez, María de los Angeles
dc.date.accessioned2014-02-06T19:07:14Z
dc.date.available2014-02-06T19:07:14Z
dc.date.issued2013-07-03
dc.identifier.citationPLoS ONE 8(7) : (2013) // e67835es
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10810/11374
dc.description9 p.es
dc.description.abstractThe European genetic landscape has been shaped by several human migrations occurred since Paleolithic times. The accumulation of archaeological records and the concordance of different lines of genetic evidence during the last two decades have triggered an interesting debate concerning the role of ancient settlers from the Franco-Cantabrian region in the postglacial resettlement of Europe. Among the Franco-Cantabrian populations, Basques are regarded as one of the oldest and more intriguing human groups of Europe. Recent data on complete mitochondrial DNA genomes focused on macrohaplogroup R0 revealed that Basques harbor some autochthonous lineages, suggesting a genetic continuity since pre-Neolithic times. However, excluding haplogroup H, the most representative lineage of macrohaplogroup R0, the majority of maternal lineages of this area remains virtually unexplored, so that further refinement of the mtDNA phylogeny based on analyses at the highest level of resolution is crucial for a better understanding of the European prehistory. We thus explored the maternal ancestry of 548 autochthonous individuals from various Franco-Cantabrian populations and sequenced 76 mitogenomes of the most representative lineages. Interestingly, we identified three mtDNA haplogroups, U5b1f, J1c5c1 and V22, that proved to be representative of Franco-Cantabria, notably of the Basque population. The seclusion and diversity of these female genetic lineages support a local origin in the Franco-Cantabrian area during the Mesolithic of southwestern Europe, similar to 10,000 years before present (YBP), with signals of expansions at similar to 3,500 YBP. These findings provide robust evidence of a partial genetic continuity between contemporary autochthonous populations from the Franco-Cantabrian region, specifically the Basques, and Paleolithic/Mesolithic hunter-gatherer groups. Furthermore, our results raise the current proportion (approximate to 15%) of the Franco-Cantabrian maternal gene pool with a putative pre-Neolithic origin to approximate to 35%, further supporting the notion of a predominant Paleolithic genetic substrate in extant European populations.es
dc.description.sponsorshipFunds were provided by the Basque Government (Grupo Consolidado IT-424-07) and a grant from the University of the Basque Country UPV/EHU (ELDUNANOTEK UFI11/32). Leire Palencia is a PhD student granted by the Basque Government (Dpto. de Educacion, Universidades e Investigacion). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectconsanguinityes
dc.subjectdiversityes
dc.subjectEuropees
dc.subjecthaplogroupses
dc.subjectmitochondrial DNAes
dc.subjectpaleogeneticses
dc.subjectphylogeneticses
dc.subjectphylogeographyes
dc.subjectpopulation geneticses
dc.subjectY chromosomees
dc.titleThe Expanded mtDNA Phylogeny of the Franco-Cantabrian Region Upholds the Pre-Neolithic Genetic Substrate of Basqueses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder©2013 Cardoso et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0067835es
dc.identifier.doi10.1371/journal.pone.0067835
dc.departamentoesBioquímica y biología moleculares_ES
dc.departamentoesZoología y biología celular animales_ES
dc.departamentoesGenética, antropología física y fisiología animales_ES
dc.departamentoeuBiokimika eta biologia molekularraes_ES
dc.departamentoeuZoologia eta animalia zelulen biologiaes_ES
dc.departamentoeuGenetika,antropologia fisikoa eta animalien fisiologiaes_ES
dc.subject.categoriaAGRICULTURAL AND BIOLOGICAL SCIENCES
dc.subject.categoriaMEDICINE
dc.subject.categoriaBIOCHEMISTRY AND MOLECULAR BIOLOGY


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