Now showing items 1-5 of 5
Characterization and pharmacological modulation of calcium handling proteins in Limb-Girdle Muscle Dystrophy type R1
Limb-girdle muscle dystrophy type R1 (LGMDR1) is the most common form of limb-girdle muscle dystrophy, currently with no effective treatment. LGMDR1 is caused by mutations in the CAPN3 gene and is characterized by reduced ...
Synaptic dysfunction in Parkinson's Disease: functional and ultrastructural study of the striatal synapses in an animal model of progressive parkinsonism
This Ph.D. project involves the temporal sequence of the earliest functional and structural events in the striatal synapses in a rat model of progressive parkinsonism induced by overexpression of human ¿-synuclein (h¿-syn) ...
Atxikimendua eta Aurpegi-Emozioen Antzematea Mugako Nortasunaren Nahasmendua duten Pazienteetan
Mugako Nortasunaren Nahasmendua (MNN) atxikimenduaren zailtasunekin lotu izan da, helduaroan bereziki atxikimendu-antsietate maila altuarekin. Bestalde, MNN-n Aurpegi-Emozioen Antzematea (AEA) aztertu dituzten ikerketetan ...
Transcriptome regulation network in Multiple sclerosis: Role of circular RNAs.
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, that leads to neurological disability. The disease course and clinical phenotype are highly variable and therefore, biomarkers that can ...
Characterization of the Isoforms of the Multiple Sclerosis Risk Protein, IL-22 Binding Protein (IL-22BP)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells (IL-22 binding protein isoform-1 [IL-22BPi1], -2 [IL-22BPi2], and -3 [IL-22BPi3]). Two of these, namely, IL-22BPi2 and IL-22BPi3, are capable of ...