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Osteopontin: a key regulator of liver lipid metabolism
(2016-04-25)
Osteopontin deficiency protects from obesity-related hepatosteatosis and liver fibrosis. Here we have investigated the role of osteopontin as a direct regulator of liver metabolism and whether osteopontin could be a ...
The role of seas as a geographical barrier for migratory landbirds. An approach to the Bay of Biscay.
(2016-11-24)
The East-Atlantic flyway represents one of the main bird migration routes worldwide, comprising the Bay of Biscayas an inherent geographical barrier. So far, the significance of the Bay of Biscay for migrants and its ...
Post-translational modifications by sumo and ubiquitin-like proteins; role of sumoylation on sall proteins
(2016-02-18)
Las modificaciones post-traduccional debidas a la conjugación de Ubiquitina y de proteínas similares a la Ubiquitina (UbLs) contribuyen a extender y diversificar la funcionalidad de los proteomas eucariotas. SUMO (Small ...
Metabolic alterations in prostate cancer pathogenesis
(2016-09-16)
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs thatsustain cell growth, proliferation and promote cancer initiation and progression. In this thesis workwe describe a novel molecular mechanism ...
Physical principles underlying structure, mechanics and dynamic re-organization of hyaluronan-rich matrices - from tissues to supramolecular models in experiment and theory
(2016-07-29)
The goal of this research project is to understand the physical principles that underlie the structure, mechanics and dynamic reorganization of hyaluronan-rich pericellular and extracellular matrices. Many cells produce a ...
Discovery and study of small RNAs in Escherichia coli using custom microarrays and next generation sequencing
(2016-12-15)
Los small RNAs (sRNAs) son moléculas de ARN no codificantes de corta longitud queregulan la estabilidad y traducción de ARN mensajeros (sus mRNA dianas), y que amenudo están implicados en el control de respuestas bacterianas ...
Mycobacteria in rabbits: Searching for an efficient paratuberculosis infection model
(2016-12-16)
La paratuberculosis es una enfermedad intestinal granulomatosa crónica, producida por Mycobacterium avium subsp paratuberculosis (Map) perteneciente al complejo mycobacterium avium (MAC). Esta enfermedad que afecta ...
Functional implication of gwas candidate genes in celiac disease pathogenesis
(2016-09-09)
La enfermedad celíaca (EC) es una enfermedad autoinmune que se desarrolla en personas con susceptibilidad genética. En los últimos años se han realizado diversos estudios de asociación genómica, en los que se han identificado ...
Study of Aspergillus fumigatus pathogenicity and identification of putative virulence genes
(2016-12-02)
Aspergillus fumigatus is considered to be the most prevalent airborne pathogenic fungus. lts infection begins with conidial germination in lungs where different types of aspergillosis can be developed. In profoundly ...