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dc.contributor.authorDacosta Aguayo, Rosalía
dc.contributor.authorGraña Romay, Manuel María
dc.contributor.authorFernández-Andújar, Marina
dc.contributor.authorLópez-Cancio, Elena
dc.contributor.authorCáceres, Cynthia
dc.contributor.authorBargalló, Núria
dc.contributor.authorBarrios, Maite
dc.contributor.authorClemente, Immaculada
dc.contributor.authorTorán Monserrat, Pere
dc.contributor.authorAlzamora Sas, Maite
dc.contributor.authorDávalos, Antoni
dc.contributor.authorAuer, Tibor
dc.contributor.authorMataró, María
dc.date.accessioned2016-02-26T11:39:02Z
dc.date.available2016-02-26T11:39:02Z
dc.date.issued2014-01-24
dc.identifier.citationPLOS ONE 9(1) : (2014) // Article ID e86119es
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10810/17440
dc.description.abstractAfter stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of the contralateral hemisphere is associated with degree of functional impairment. Fourteen patients suffering right hemispheric focal stroke (S) and eighteen healthy controls (HC) underwent Diffusion Weighted Imaging (DWI) and neuropsychological assessment. The stroke patient group was divided into poor (SP; n = 8) and good (SG; n = 6) cognitive recovery groups according to their cognitive improvement from the acute phase (72 hours after stroke) to the subacute phase (3 months post-stroke). Whole-brain DWI data analysis was performed by computing Diffusion Tensor Imaging (DTI) followed by Tract Based Spatial Statistics (TBSS). Assessment of effects was obtained computing the correlation of the projections on TBSS skeleton of Fractional Anisotropy (FA) and Radial Diffusivity (RD) with cognitive test results. Significant decrease of FA was found only in right brain anatomical areas for the S group when compared to the HC group. Analyzed separately, stroke patients with poor cognitive recovery showed additional significant FA decrease in several left hemisphere regions; whereas SG patients showed significant decrease only in the left genu of corpus callosum when compared to the HC. For the SG group, whole brain analysis revealed significant correlation between the performance in the Semantic Fluency test and the FA in the right hemisphere as well as between the performance in the Grooved Pegboard Test (GPT) and theTrail Making Test-part A and the FA in the left hemisphere. For the SP group, correlation analysis revealed significant correlation between the performance in the GPT and the FA in the right hemisphere.es
dc.description.sponsorshipThis project has been made possible primarily through the efforts of the authors' recruited patients and healthy controls participants who voluntarily accepted to enroll in this project. This study was supported by the grants PSI2009-11519 to MM, the grant Formacio Personal Investigador (FPI), BES-2010-031833 to MF from the Ministry of Science and Innovation (MICINN), grant TIN2011-23823 from the Ministry of Economy and Competitiveness (MINECO) and UFI 11/07 to MG, Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es
dc.language.isoenges
dc.publisherPublic Library Sciencees
dc.relationinfo:eu-repo/grantAgreement/MICINN/BES-2010-031833
dc.relationinfo:eu-repo/grantAgreement/MINECO/TIN2011-23823
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectwhite-matter integrityes
dc.subjectfocal cerebral -ischemiaes
dc.subjecttensor imaging-detectses
dc.subjectdiffusion anisotropyes
dc.subjectmotor functiones
dc.subjecttractes
dc.subjectratses
dc.subjectinjuryes
dc.subjectMRIes
dc.subjectdegenerationes
dc.titleStructural Integrity of the Contralesional Hemisphere Predicts Cognitive Impairment in Ischemic Stroke at Three Monthses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder2014 Dacosta-Aguayo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086119#abstract0es
dc.identifier.doi10.1371/journal.pone.0086119
dc.departamentoesCiencia de la computación e inteligencia artificiales_ES
dc.departamentoesNeurocienciases_ES
dc.departamentoeuKonputazio zientziak eta adimen artifizialaes_ES
dc.departamentoeuNeurozientziakes_ES
dc.subject.categoriaAGRICULTURAL AND BIOLOGICAL SCIENCES
dc.subject.categoriaMEDICINE
dc.subject.categoriaBIOCHEMISTRY AND MOLECULAR BIOLOGY


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