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dc.contributor.authorPérez Cerdá, Fernando
dc.contributor.authorSánchez Gómez, María Victoria
dc.contributor.authorMatute Almau, Carlos José
dc.date.accessioned2016-04-11T14:10:04Z
dc.date.available2016-04-11T14:10:04Z
dc.date.issued2015-07-07
dc.identifier.citationFrontiers in neuroanatomy 7 : (2015) // Article ID 92es
dc.identifier.issn1662-5129
dc.identifier.issn10.3389/fnana.2015.00092
dc.identifier.urihttp://hdl.handle.net/10810/17881
dc.description.abstractRio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas Achucarro from whom he learned the use of metallic impregnation techniques suitable to study non-neuronal cells. Later on, he joined Cajal's laboratory. and Subsequently, he created his own group, where he continued to develop other innovative modifications of silver staining methods that revolutionized the study of glial cells a century ago. He was also interested in neuropathology and became a leading authority on Central Nervous System (CNS) tumors. In parallel to this clinical activity, del Rio Hortega rendered the first systematic description of a major polymorphism present in a subtype of macroglial cells that he named as oligodendroglia and later OLGs. He established their ectodermal origin and suggested that they built the myelin sheath of CNS axons, just as Schwann cells did in the periphery. Notably, he also suggested the trophic role of OLGs for neuronal functionality, an idea that has been substantiated in the last few years. Del Rio Hortega became internationally recognized and established an important neurohistological school with outstanding pupils from Spain and abroad, which nearly disappeared after his exile due to the Spanish civil war. Yet, the difficulty of metal impregnation methods and their variability in results, delayed for some decades the confirmation of his great insights into oligodendrocyte biology until the development of electron microscopy and immunohistochemistry. This review aims at summarizing the pioneer and essential contributions of del Rio Hortega to the current knowledge of oligodendrocyte structure and function, and to provide a hint of the scientific personality of this extraordinary and insufficiently recognized man.es
dc.description.sponsorshipWork in our laboratory is funded by CIBERNED, Gobierno Vasco (EJ/GV) and MINECO (SAF2013-45084-R). We thank MM Panicker for reading the manuscript.es
dc.language.isoenges
dc.publisherFrontiers Research Foundationes
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF2013-45084-R
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDel Rio Hortegaes
dc.subjectmyelin sheathes
dc.subjectoligodendrogliaes
dc.subjectoligodendrocyte precursor cell (OPC)es
dc.subjectRamon y Cajales
dc.subjectschooles
dc.titlePio del Rio Hortega and the discovery of the oligodendrocyteses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2015 Pérez-Cerdá, Sánchez-Gómez and Matute. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fnana.2015.00092/full#h1es
dc.departamentoesNeurocienciases_ES
dc.departamentoeuNeurozientziakes_ES
dc.subject.categoriaANATOMY AND MORPHOLOGY
dc.subject.categoriaNEUROSCIENCES
dc.subject.categoriaCELLULAR AND MOLECULAR NEUROSCIENCE


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