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dc.contributor.authorSánchez Sánchez, Ana Belén
dc.contributor.authorPomposo Alonso, José Adolfo
dc.date.accessioned2016-05-10T10:44:18Z
dc.date.available2016-05-10T10:44:18Z
dc.date.issued2015
dc.identifier.citationJournal of nanomaterials 2015 : (2015) // Article ID723492es
dc.identifier.issn1687-4110
dc.identifier.issn1687-4129
dc.identifier.urihttp://hdl.handle.net/10810/18209
dc.description.abstractSingle-chain technology (SCT) allows the transformation of individual polymer chains to folded/collapsed unimolecular soft nanoparticles. In this work we contribute to the enlargement of the SCT toolbox by demonstrating the efficient synthesis of single-chain polymer nanoparticles (SCNPs) via intrachain amide formation. In particular, we exploit cross-linking between active methylene groups and isocyanate moieties as powerful "click" chemistry driving force for SCNP construction. By employing poly(methyl methacrylate)- (PMMA-) based copolymers bearing beta-ketoester units distributed randomly along the copolymer chains and bifunctional isocyanate cross-linkers, SCNPs were successfully synthesized at r.t. under appropriate reaction conditions. Characterization of the resulting SCNPs was carried out by means of a combination of techniques including size exclusion chromatography (SEC), infrared (IR) spectroscopy, proton nuclear magnetic resonance (H-1 NMR) spectroscopy, dynamic light scattering (DLS), and elemental analysis (EA).es
dc.description.sponsorshipFinancial support from Projects MAT2012-31088 (MINE-CO), T-654-13 (GV), and S-PE13UN034 (GV) is acknowledged. Ana Sanchez-Sanchez thanks the Ph.D. grant support of Basque Government.es
dc.language.isoenges
dc.publisherHindawi Publishinges
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectintramolecular cross-linkinges
dc.subjectclick chemistryes
dc.subjectpolistyrene nanoparticleses
dc.subjectdisordered proteinses
dc.subjectcollapsees
dc.subjectcovalentes
dc.subjectmacromoleculeses
dc.subjectnoncovalentes
dc.subjectroutees
dc.subjectbondises
dc.titleEfficient Synthesis of Single-Chain Polymer Nanoparticles via Amide Formationes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2015 A. Sanchez-Sanchez and J. A. Pomposo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es
dc.relation.publisherversionhttp://www.hindawi.com/journals/jnm/2015/723492/abs/es
dc.identifier.doi10.1155/2015/723492
dc.departamentoesFísica de materialeses_ES
dc.departamentoeuMaterialen fisikaes_ES
dc.subject.categoriaMATERIALS SCIENCE


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