Now showing items 1-6 of 6
Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis
(Public Library Science, 2015-04-15)
Background Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ...
Pio del Rio Hortega and the discovery of the oligodendrocytes
(Frontiers Research Foundation, 2015-07-07)
Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ...
From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia
(Frontiers Research Foundation, 2015-04-14)
Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, ...
Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation
Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 ...
Regulación de las GTPasas de la familia Ras y la viabilidad de neuronas dopaminérgicas en respuesta a la señalización purinérgica
El ATP es una molécula natural cuya liberación descontrolada puede elevar su concentración extracelular a rango mM y promover la estimulación de receptores purinérgicos. Se sabe que esta estimulación tiene efectos citotóxicos ...
FTY720 attenuates excitotoxicity and neuroinflammation
(BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...