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Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis 

González Ortega, Itxaso; Alberich, Susana; Echeburúa Odriozola, Enrique; Aizpuru Barandiaran, Felipe; Millán, Eduardo; Vieta, Eduard; Matute Almau, Carlos José; González Pinto Arrillaga, Ana María (Public Library Science, 2015-04-15)
Background Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ...
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Pio del Rio Hortega and the discovery of the oligodendrocytes 

Pérez Cerdá, Fernando; Sánchez Gómez, María Victoria; Matute Almau, Carlos José (Frontiers Research Foundation, 2015-07-07)
Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ...
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Neurotransmitter signaling in the pathophysiology of microglia 

Domercq García, María; Vázquez Villoldo, Nuria; Matute Almau, Carlos José (Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
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Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis 

Ruiz de Azúa Garcia, Sonia; Matute Almau, Carlos José; Stertz, Laura; Mosquera, Fernando; Palomino Fernández de Larrea, Aitor; De la Rosa, Iris; Barbeito, Sara; Vega, Patricia; Kapczinski, Flavío; González Pinto Arrillaga, Ana María (BioMed Central, 2013)
Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain ...
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CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels 

Ruiz Núñez, Asier; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)
Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ...
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Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis 

Lutz, Sarah E.; González Fernández, Estibaliz; Chara Ventura, Juan Carlos; Pérez Samartín, Alberto Luis; Tarassishin, Leonid; Negoro, Hiromitsu; Patel, Naman K.; Suadicani, Sylvia O.; Lee, Sunhee C.; Matute Almau, Carlos José; Scemes, Eliana (Public Library of Science, 2013-06)
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. ...
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NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation 

Cavaliere, Fabio; Benito Muñoz, Mónica; Panicker, Mitradas; Matute Almau, Carlos José (Frontiers Research Foundation, 2013-12-18)
Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ...
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Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate 

Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2012-02)
We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ...
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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier; Apraiz, A.; Arrizabalaga, O.; Vellon, L.; Alberdi Alfonso, Elena María; Cavaliere, Fabio; Lacerda, H. M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
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Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine 

Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; Matute Almau, Carlos José; Sánchez Gómez, María Victoria; Domercq García, María; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...
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Matute Almau, Carlos José (11)
Alberdi Alfonso, Elena María (3)Cavaliere, Fabio (3)Chara Ventura, Juan Carlos (2)... View MoreDepartamento (cas.)Neurociencias (11)Genética, antropología física y fisiología animal (1)Departamento (eus.)
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