Pharmacokinetics and metabolomics in paediatric studies

Blanco Arana, María Encarnación

dc.contributor.advisor	Alonso Rojas, Rosa María
dc.contributor.advisor	González Mendia, Oscar
dc.contributor.author	Blanco Arana, María Encarnación
dc.contributor.other	Química Analítica;;Kimika Analitikoa	es
dc.date.accessioned	2017-03-14T10:24:26Z
dc.date.available	2017-03-14T10:24:26Z
dc.date.issued	2016-03-14
dc.date.submitted	2016-03-14
dc.identifier.uri	http://hdl.handle.net/10810/20936
dc.description	113 p.	es
dc.description.abstract	One of the main problems encountered in clinical pharmacology is the lack of information available for pharmaceutical drugs in paediatric population. As a result, many drugs are used off-label, and the doses are adjusted using empirical algorithms from allometric models optimised for adults. However, this does not take into consideration the different grades of maturation of the organs involved in the absorption, distribution, metabolism and elimination (ADME) processes of drugs in children. To address this problematic two approaches are presented in this thesis: the evaluation of pharmacokinetic predictive models in paediatric population and the use of metabolomics as an innovative tool to differentiate the grades of maturation in paediatrics.	es
dc.language.iso	eng	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	biochemical analysis	es
dc.subject	chromatographic analysis	es
dc.subject	mass spectroscopy	es
dc.subject	química análitica	es
dc.subject	análisis cromatográfico	es
dc.subject	espectroscopia de masas	es
dc.title	Pharmacokinetics and metabolomics in paediatric studies	es
dc.type	info:eu-repo/semantics/doctoralThesis	es
dc.rights.holder	(cc)2016 MARIA ENCARNACION BLANCO ARANA (cc by-nc-nd 4.0)
dc.identifier.studentID	346982	es
dc.identifier.projectID	14601	es
dc.departamentoes	Química analítica	es_ES
dc.departamentoeu	Kimika analitikoa	es_ES