Now showing items 21-40 of 77

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      Data on Links Between Structural and Functional Prokaryotic Diversity in Long-Term Sewage Sludge Amended Soil 

      Urra Ibañez de Sendadiano, Julen; Alcorta Calvo, Miren Itziar; Mijangos Amezaga, Iker; Garbisu Crespo, Carlos (Elsevier, 2018-09-12)
      The application of sewage sludge to agricultural soil induces co-exposure of prokaryotic populations to antibiotics and heavy metals, thus exerting a selection pressure that may lead to the development of antibiotic ...
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      DNA methylation epigenotypes in breast cancer molecular subtypes 

      García Bediaga, Naiara; Acha Sagredo, Amelia; Guerra, Isabel; Viguri, Amparo; Albaina, Carmen; Ruiz Díaz, Irune; Rezola, Ricardo; Alberdi, María Jesús; Dopazo, Joaquín; Montaner, David; Renobales Scheifler, María Mercedes de; Fernández Fernández, Agustín; Field, John K.; Fraga, Mario F.; Liloglou, Liloglou; Martínez de Pancorbo Gómez, María de los Angeles (BioMed Central, 2010-09-29)
      Introduction: Identification of gene expression-based breast cancer subtypes is considered a critical means of prognostication. Genetic mutations along with epigenetic alterations contribute to gene-expression changes ...
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      Exploring The Role Of Genome And Structural Ions In Preventing Viral Capsid Collapse During Dehydration 

      Martín González, Natalia; Guerin Darvas, Sofia Marina; Durana, Aritz; Marti, Gerardo A.; Guerín Aguilar, Diego Marcelo A.; De Pablo, Pedro J. (IOP Publishing, 2018-03-14)
      Even though viruses evolve mainly in liquid milieu, their horizontal transmission routes often include episodes of dry environment. Along their life cycle, some insect viruses, such as viruses from the Dicistroviridae ...
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      Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused Disease 

      Benito Vicente, Asier; Belloso Uribe, Kepa; Jebari Benslaiman, Shifa; Galicia García, Unai; Ostolaza Echabe, Elena Amaya; Martín Plágaro, César Augusto (MDPI, 2018-11-01)
      Cholesterol is an essential component of cell barrier formation and signaling transduction involved in many essential physiologic processes. For this reason, cholesterol metabolism must be tightly controlled. Cell cholesterol ...
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      Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum 

      Santos, João D.; Canato, Sara; Carvalho, Ana S.; Botelho, Hugo M.; Aloria Escolastico, Kerman; Amaral, Margarida D.; Matthiesen, Rune; Falcao, Andre O.; Farinha, Carlos M. (MDPI, 2019-04-14)
      The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention ...
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      Highlights of the 2nd International Symposium on Tribbles and Diseases: Tribbles Tremble in Therapeutics for Immunity, Metabolism, Fundamental Cell Biology and Cancer 

      Cui, Bing; Eyers, Patrick A.; Dobens, Leonard L.; Tan, Nguan Soon; Mace, Peter D.; Link, Wolfgang A.; Kiss Toth, Endre; Keeshan, Karen; Nakamura, Takuro; Pear, Warren S.; Feseha, Yodit; Johnston, Jessica; Carracedo Pérez, Arkaitz; Scheideler, Marcel; llyas, Zabran; Bauer, Robert C.; Erusalimsky, Jorge D.; Grzesik, Dominika; Salamanca Viloria, Juan; Lv, Xiaoxi; Jin, Yishi; Li, Ke; Velasco, Guillermo; Shang, Shuang; Lizcano de Vega, José Miguel; Zhang, Xiaowei; Zhou, Jichao; Yu, Jiaojiao; Hua, Fang; Wang, Feng; Liu, Shanshan; Yu, Jinmei; Hu, Zhuowei (Institute of Materia Medica, 2019-03)
      The Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB ...
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      HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1 

      Izquierdo-Useros, Nuria; Lorizate Nogales, Maier; McLaren, Paul J.; Telenti, Amalio; Kräusslich, Hans-Georg; Martinez-Picado, Javier (Public Library Science, 2014-07)
      Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism ...
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      Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge 

      Hervás Hidalgo, Javier; Landajuela Larma, Ane; Antón Helas, Zuriñe; Shnyrova Zhadan, Anna V.; Goñi Urcelay, Félix María; Alonso Izquierdo, Alicia (Nature Publishing, 2017-11-15)
      Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG) proteins to the nascent membrane during autophagosome (AP) formation. ATG3, a key protein in the movement of LC3 towards the ...
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      Human LDL Structural Diversity Studied by IR Spectroscopy 

      Fernández Higuero, José Ángel; Salvador, Ana M.; Martín Plágaro, César Augusto; González Milicua, José Carlos; Rodríguez Arrondo, José Luis (Public Library Science, 2014-03-18)
      Lipoproteins are responsible for cholesterol traffic in humans. Low density lipoprotein (LDL) delivers cholesterol from liver to peripheral tissues. A misleading delivery can lead to the formation of atherosclerotic plaques. ...
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      ICTV Virus Taxonomy Profile:PolycipiviridaeIngrida 

      Olendraite, Ingrida; Brown, Katherine; Valles, Steven M.; Firth, Andrew E.; Chen, Yanping; Guerín Aguilar, Diego Marcelo A.; Hashimoto, Yoshifumi; Herrero, Salvador; Rodrigues de Miranda, Joachim; Ryabov, Eugene; ICTV Report Consortium (Microbiology Society, 2019-04)
      Polycipiviridae is a family of picorna-like viruses with non-segmented, linear, positive-sense RNA genomes of approximately 10-12 kb. Unusually for viruses within the order Picornavirales, their genomes are polycistronic, ...
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      In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets 

      Segura, Victor; Valero, M. Luz; Cantero, Laura; Muñoz, Javier; Zarzuela, Eduardo; García, Fernando; Aloria Escolastico, Kerman; Beaskoetxea Lejarzegi, Javier; Arizmendi Bastarrika, Jesús María; Navajas, Rosana; Paradela, Alberto; Díez, Paula; Degano, Rosa M.; Fuentes, Manuel; Orfao, Alberto; García Montero, Andrés; Garin-Muga, Alba; Corrales, Fernando J.; Sánchez del Pino, Manuel M. (MDPI, 2018-02-05)
      Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression ...
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      Inoculation of Triatoma Virus (Dicistroviridae: Cripavirus) elicits a non-infective immune response in mice 

      Querido, Jailson F. B.; Agirre, Jon; Martí, Gerardo A.; Guerín Aguilar, Diego Marcelo A.; Silva, Marcelo Sousa (Biomed Central, 2013-03)
      Background: Dicistroviridae is a new family of small, non-enveloped, +ssRNA viruses pathogenic to both beneficial arthropods and insect pests. Little is known about the dicistrovirus replication mechanism or gene function, ...
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      Integrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Cancer 

      Valcárcel Jiménez, Lorea; Macchia, Alice; Martín Martín, Natalia; Cortazar, Ana Rosa; Schaub Clerigué, Ariane; Pujana Vaquerizo, Mikel; Fernández Ruiz, Sonia; Lacasa Viscasillas, Isabel; Santos Martín, Aida; Loizaga Iriarte, Ana; Unda Urzaiz, Jesús Miguel; Hermanova, Ivana; Astobiza Pérez, Janire; Graupera, Mariona; Julia, Starkova; Sutherland, James; Barrio Olano, Rosa; Aransay Bañares, Ana María; Carracedo Pérez, Arkaitz; Torrano Moya, Verónica (Nature Publishing Group, 2018-10-11)
      The dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity ...
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      Kv7 Channels Can Function without Constitutive Calmodulin Tethering 

      Gómez Posada, Juan Camilo; Aivar, Paloma; Alberdi González, Araitz; Alaimo Campi, Alessandro; Etxeberria, Ainhoa; Fernández-Orth, Juncal; Zamalloa Echevarría, Teresa; Roura-Ferrer, Meritxell; Villace Lozano, Patricia; Areso Goiricelaya, María Pilar; Casis Sáenz, Oscar; Villarroel Muñoz, Álvaro (Public Library of Science, 2011-09-28)
      M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 ...
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      Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport 

      Arregi Vado, Igor; Falces, Jorge; Olazabal Herrero, Ane; Alonso Mariño, Marian; Taneva, Stefka G.; Rodríguez Pérez, José Antonio; Urbaneja Arrue, María Ángeles; Bañuelos Rodríguez, Sonia (Public Library of Science, 2015-06-19)
      Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia ...
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      Magnetic Cross-Linked Enzyme Aggregates (mCLEAs) of Candida antarctica Lipase: An Efficient and Stable Biocatalyst for Biodiesel Synthesis 

      Cruz Izquierdo, Álvaro; Picó, Enrique A.; López, Carmen; Serra Ferrer, Juan Luis; Llama Fontal, María Jesús (Public Library Science, 2014-12-31)
      Enzyme-catalyzed production of biodiesel is the object of extensive research due to the global shortage of fossil fuels and increased environmental concerns. Herein we report the preparation and main characteristics of a ...
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      Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins 

      Etxaniz Iriondo, Asier; González Bullón, David; Martín Plágaro, César Augusto; Ostolaza Echabe, Elena Amaya (MDPI, 2018-06-09)
      Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria produce pore-forming toxins that break ...
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      Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression 

      Clos-Garcia, Marc; Loizaga Iriarte, Ana; Zuñiga García, Patricia; Sánchez Mosquera, Pilar; Cortázar, Ana Rosa; González, Esperanza; Verónica Torrano; Alonso, Cristina; Pérez Cormenzana, Miriam; Ugalde Olano, Aitziber; Lacasa Viscasillas, Isabel; Castro, Azucena; Royo, Félix; Unda Urzaiz, Jesús Miguel; Carracedo Pérez, Arkaitz; Falcón Pérez, Juan M. (Taylor & Francis, 2018-05-07)
      Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have ...
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      Molecular Recognition of the Native HIV-1 MPER Revealed by STED Microscopy of Single Virions 

      Carravilla Palomanes, Pablo; Chojnacki, Jakub; Rujas Díez, Edurne; Insausti González, Sara; Largo Pereda, Eneko; Waithe, Dominic; Apellaniz Unzalu, Beatriz; Sicard, Taylor; Julien, Jean Philippe; Eggeling, Christian; Nieva Escandón, José Luis (Springer, 2019-01-08)
      Antibodies against the Membrane-Proximal External Region (MPER) of the Env gp41 subunit neutralize HIV-1 with exceptional breadth and potency. Due to the lack of knowledge on the MPER native structure and accessibility, ...
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      Molecular Techniques for Dicistrovirus Detection without RNA Extraction or Purification 

      Querido, Jailson F. B.; Agirre, Jon; Martí, Gerardo A.; Guerín Aguilar, Diego Marcelo A.; Silva, Marcelo Sousa (Hindawi Publishing Corporation, 2013)
      Dicistroviridae is a new family of small, nonenveloped, and +ssRNA viruses pathogenic to both beneficial arthropods and insect pests as well. Triatoma virus (TrV), a dicistrovirus, is a pathogen of Triatoma infestans ...