BackExaminar Artículos por departamento (eus.) "Neurozientziak"
Now showing items 21-40 of 330
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Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
(Frontiers Media, 2020-07-21)Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe ... -
Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy
(Nature Publishing Group, 2014-05)Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be ... -
Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia
(Frontiers Media, 2021-02-03)Microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as Alzheimer's disease (AD). Due to the many limitations to study microglia ... -
Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease
Ortiz Sanz, Carolina; Balantzategi Fernández de Arroiabe, Uxue; Quintela López, Tania; Ruiz Núñez, Asier
; Luchena Moreno, Celia ; Zuazo Ibarra, Jone; Capetillo González de Zarate, Estibaliz; ; Zugaza Gurruchaga, José Luis ; Alberdi Alfonso, Elena María (SpringerNature, 2022-03-19)
[EN] Amyloid beta (Abeta)-mediated synapse dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and previous studies suggest that NMDA receptor (NMDAR) dysregulation may contribute to these pathological ... -
Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach
(Wolters Kluwer, 2019-02)Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to ... -
An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial
Berriozabalgoitia, Rakel; ; ; ; Yeregui Prieto, Izaskun ; ; Duñabeitia Usategui, Iratxe ; ; Domercq García, María ; Irazusta Astiazaran, Jon ; (Frontiers Media, 2020)
Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable ... -
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
(Genetics Society of America, 2016-07-01)Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) ... -
Annual Research Review: Prevention of Psychosis in Adolescents - Systematic Review and Meta-Analysis of Advances in Detection, Prognosis and Intervention
Catalán Alcántara, Ana; Salazar de Pablo, Gonzalo ; Vaquerizo Serrano, Julio; Mosillo, Pierluca; Baldwin, Helen; Fernández Rivas, Aranzazu; Moreno, Carmen; Arango, Celso; Correll, Christoph U.; Bonoldi, Ilaria; Fusar-Poli, Paolo (Wiley, 2021-05)
Background The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less ... -
Antioxidant defense system and family environment in adolescents with family history of psychosis
González Pinto Arrillaga, Ana María; Martínez Cengotitabengoa, Mónica ; ; ; ; ; ; ; (BioMed Central, 2012-11-16)
[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with ... -
APP depletion alters selective pre- and post-synaptic proteins
(Elsevier, 2019-03)The normal role of Alzheimer's disease (AD)-linked amyloid precursor protein (APP) in the brain remains incompletely understood. Previous studies have reported that lack of APP has detrimental effects on spines and ... -
Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover
Plaza Zabala, Ainhoa; ; (Frontiers Media, 2021-01-29)
Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly ... -
Assessing care-related regret among nurses specialized in multiple sclerosis: A psychometric analysis of a new assessment battery
Ballesteros Rodríguez, Francisco Javier; ; ; ; ; ; ; ; (SAGE, 2022-10)
Experiences of regret associated with caring for patients with multiple sclerosis (MS) can affect medical decisions. A non-interventional study was conducted to assess the dimensionality and item characteristics of a battery ... -
Assessment of Pharmaceutical Mixture (Ibuprofen, Ciprofloxacin And Flumequine) Effects to the Crayfish Procambarus Clarkii: a Multilevel Analysis (Biochemical, Transcriptional and Proteomic Approaches)
; ; Montilla López, Alejandro; ; ; ; ; ; (Elsevier, 2021-05-29)
The knowledge about the effects of pharmaceuticals on aquatic organisms has been increasing in the last decade. However, due to the variety of compounds presents in the aquatic medium, exposure scenarios and exposed ... -
Assessment of Psychiatric Symptomatology in Bilingual Psychotic Patients: A Systematic Review and Meta-Analysis
Erkoreka González, Leire; ; Ruiz, Onintze; Ballesteros Rodríguez, Francisco Javier (MDPI, 2020-06-10)
Language plays an important role in psychiatric conditions. Language disturbances are core symptoms of psychiatric ailments, and language is the main diagnostic tool to assess psychopathological severity. Although the ... -
Assisted Reproductive Techniques in Multiple Sclerosis: Recommendations from an Expert Panel
(Springer, 2023-04)Introduction Multiple sclerosis (MS) is mainly diagnosed in women of reproductive age. However, there is a paucity of guidelines jointly prepared by neurologists and gynaecologists on managing women with MS and the desire ... -
Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania
García Fernández, Saínza; Alberich, Susana; MacDowell, Karina S.; Martínez Cengotitabengoa, Mónica ; López Peña, María Purificación; Zorrilla Martínez, Iñaki; Leza, Juan Carlos; González Pinto Arrillaga, Ana María (Frontiers Media, 2019-03-26)
Poor adherence is a major problem in patients with manic episodes that impairs functionality and has unknown effects on oxidative stress. The objective of this study was to analyze the relationship between adherence to ... -
Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process
Bulnes Sesma, Susana; Bermúdez, Garazi; Lafuente Sánchez, José Vicente (Impact Journals LLC, 2018-07-31)
Notch-1 and osteopontin (OPN) mediate angiogenesis and glioma stem-like cell (GSLC) maintenance. However, the relationship between these molecules and GSLCs during the development of glioma is unknown. We investigate the ... -
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
(2021-03)Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive ... -
Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways
Preman, Pranav; Alfonso Triguero, Maria; Alberdi Alfonso, Elena María; Verkhratsky, Alexei; Arranz Mendiguren, Amaia (MDPI, 2021-03-04)
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. ... -
Astrocytic Atrophy as a Pathological Feature of Parkinson's Disease with LRRK2 Mutation
Ramos González, Paula; Mato Santos, Susana; Chara Ventura, Juan Carlos; Verkhratsky, Alexei; ; Cavaliere, Fabio (Springer, 2021-03-30)
The principal hallmark of Parkinson's disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to dopaminergic neurodegeneration through decreased ...