Browsing Artículos by Author "Acera Osa, Arantxa"
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A Pilot Study of a Panel of Ocular Inflammation Biomarkers in Patients with Primary Sjögren’s Syndrome
Boto de los Bueis, Ana; de la Fuente, Miguel; Montejano Milner, Rafael; del Hierro Zarzuelo, Almudena; Vecino Cordero, Elena ; Acera Osa, Arantxa (MDPI, 2023-04-01)Ocular diseases have a strong impact on individuals, the effects of which extend from milder visual impairment to blindness. Due to this and to their prevalence, these conditions constitute important health, social and ... -
Comparative lipidomic analysis of mammalian retinal ganglion cells and Muller glia in situ and in vitro using High-Resolution Imaging Mass Spectrometry
Pereiro Díez, Xandra ; Fernández, Roberto; Barreda Gómez, Gabriel; Ruzafa Andrés, Noelia ; Acera Osa, Arantxa; Araiz Iribarren, José Javier; Astigarraga Arribas, Egoitz; Vecino Cordero, Elena (Nature, 2020-11-18)In order to better understand retinal physiology, alterations to which underlie some ocular diseases, we set out to establish the lipid signature of two fundamental cell types in the retina, Muller Glia and Retinal Ganglion ... -
Comparative study of the lipid profile of tears and plasma enriched in growth factors.
Acera Osa, Arantxa; Abad García, Beatriz; Pereiro Díez, Xandra ; Rodríguez, Francisco David; Ruzafa Andrés, Noelia ; Durán de la Colina, Juan Antonio; Vecino Cordero, Elena (Elsevier, 2022-06)[EN] The Tear Film Lipid Layer (TFLL) acts primarily as an interface between the aqueous layer and air. Tear film lipid is composed of a thin layer of polar lipids that interact with the secretory layer of the underlying ... -
Dexamethasone Protects Retinal Ganglion Cells But Not Muller Glia Against Hyperglycemia In Vitro
Pereiro Díez, Xandra ; Ruzafa Andrés, Noelia ; Acera Osa, Arantxa; Fonollosa Calduch, Alejandro; Rodríguez, Francisco David; Vecino Cordero, Elena (Public Library Science, 2018-11-26)Diabetic retinopathy (DR) is a common complication of diabetes, for which hyperglycemia is a major etiological factor. It is known that retinal glia (Muller cells) and retinal ganglion cells (RGCs) are affected by diabetes, ... -
Elevation of Tear MMP-9 Concentration as a Biomarker of Inflammation in Ocular Pathology by Antibody Microarray Immunodetection Assays
De la Fuente López, Miguel; Rodríguez Agirretxe, Ignacio; Vecino Cordero, Elena ; Astigarraga Arribas, Egoitz; Acera Osa, Arantxa; Barreda Gómez, Gabriel (MDPI, 2022-05-18)Matrix metalloproteinases are a family of enzymes fundamental in inflammatory processes. Between them, MMP-9 is up-regulated during inflammation; thus, its quantification in non-invasive fluids is a promising approach for ... -
Enzyme Therapy: Current Challenges and Future Perspectives
De la Fuente López, Miguel; Lombardero, Laura; Gómez-González, Alfonso; Solari, Cristina; Angulo Barturen, Iñigo; Acera Osa, Arantxa; Vecino Cordero, Elena ; Astigarraga, Egoitz; Barreda Gómez, Gabriel (MDPI, 2021-08-25)In recent years, enzymes have risen as promising therapeutic tools for different pathologies, from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint problems, to cancer or cardiovascular ... -
Müller glial cells located in the peripheral retina are more susceptible to high pressure: implications for glaucoma
Pereiro Díez, Xandra ; Ruzafa Andrés, Noelia ; Azkargorta, Mikel; Elortza, Felix; Acera Osa, Arantxa; Ambrósio, António Francisco; Santiago, Ana Raquel; Vecino Cordero, Elena (BMC, 2024)Background Glaucoma, a progressive neurodegenerative disease, is a leading cause of irreversible vision loss worldwide. This study aims to elucidate the critical role of Müller glia (MG) in the context of retinal ganglion ... -
Plasma Rich in Growth Factors (PRGF) Increases the Number of Retinal Muller Glia in Culture but Not the Survival of Retinal Neurons
Ruzafa Andrés, Noelia ; Pereiro Díez, Xandra ; Fonollosa Calduch, Alejandro; Araiz Iribarren, José Javier; Acera Osa, Arantxa; Vecino Cordero, Elena (Frontiers Media, 2021-03-09)Plasma rich in growth factors (PRGF) is a subtype of platelet-rich plasma (PRP) that stimulates tissue regeneration and may promote neuronal survival. It has been employed in ophthalmology to achieve tissue repair in some ... -
Potential Tear Biomarkers for the Diagnosis of Parkinson’s Disease—A Pilot Study
Acera Osa, Arantxa; Gómez Esteban, Juan Carlos; Murueta-Goyena Larrañaga, Ane; Galdós Iztueta, Marta; Azkargorta, Mikel; Elortza, Felix; Ruzafa Andrés, Noelia ; Ibarrondo, Oliver; Pereiro Díez, Xandra ; Vecino Cordero, Elena (MDPI, 2022-01-13)Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, n = 24), carriers of the E46K-SNCA ... -
The Effect of Plasma Rich in Growth Factors on Microglial Migration, Macroglial Gliosis and Proliferation, and Neuronal Survival
Ruzafa Andrés, Noelia ; Pereiro Díez, Xandra ; Fonollosa Calduch, Alejandro; Araiz Iribarren, José Javier; Acera Osa, Arantxa; Vecino Cordero, Elena (Frontiers Media, 2021-02-26)Plasma rich in growth factors (PRGF) is a subtype of platelet-rich plasma that has being employed in the clinic due to its capacity to accelerate tissue regeneration. Autologous PRGF has been used in ophthalmology to repair ...