Now showing items 1-20 of 40

    • Thumbnail

      A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene 

      Ibarrola Villava, Maider; Fernandez, Lara P.; Alonso Alegre, Santos; Boyano López, María Dolores; Peña Chilet, María; Pita, Guillermo; Avilés, José A.; Mayor, Matias; Gómez Fernández, Cristina; Casado, Beatriz; Martín González, Manuel; Izagirre Arribalzaga, Neskuts; De la Rúa Vaca, Concepción; Asumendi Mallea, Aintzane; Pérez-Yarza Pérez-Irezabal, Gorka; Arroyo Berdugo, Yoana; Boldo, Enrique; Lozoya, Rafael; Torrijos Aguilar, Arantxa; Pitarch, Ana; Pitarch, Gerard; Sánchez Motilla, José M.; Valcuende Cavero, Francisca; Tomás Cabedo, Gloria; Pérez Pastor, Gemma; Díaz Pérez, José Luis; Gardeazabal García, Jesús; Martínez de Lizarduy, Iñigo; Sánchez Diez, Ana; Valdés, Carlos; Pizarro, Angel; Casado, Mariano; Carretero, Gregorio; Botella Estrada, Rafael; Nagore, Eduardo; Lázaro, Pablo; Lluch, Ana; Benítez, Javier; Martínez Cadenas, Conrado; Ribas, Gloria (Public Library of Science, 2011-04-29)
      As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ...
    • Thumbnail

      A novel brain partition highlights the modular skeleton shared by structure and function 

      Diez Palacio, Ibai; Bonifazi, Paolo; Escudero, Iñaki; Mateos, Beatriz; Muñoz, Miguel A.; Stramaglia, Sebastiano; Cortés Díaz, Jesús María (Nature Publishing Group, 2015-06-03)
      Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent progress in neuroimaging has helped advance our ...
    • Thumbnail

      Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells 

      Martín Plágaro, César Augusto; Etxaniz Iriondo, Asier; Belloso Uribe, Kepa; Etxebarria Gallego, Aitor; González Bullón, David; Arlucea de Jaureguizar, Jon Andoni; Goñi Urcelay, Félix María; Arechaga Martínez, Juan Miguel; Ostolaza Echabe, Elena Amaya (Nature Publishing Group, 2015-09-08)
      Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium ...
    • Thumbnail

      An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability 

      Mitxelena Sánchez, Jone; Apraiz García, Aintzane; Vallejo Rodríguez, Jon; García Santisteban, Iraia; Fullaondo Elordui-Zapaterieche, Asier; Alvarez Fernández, Mónica; Marcos, Marcos; Zubiaga Elordieta, Ana María (Oxford University Press, 2018-05-18)
      The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ...
    • Thumbnail

      Are environmental risk factors for current wheeze in the International Study of Asthma and Allergies in Childhood (ISAAC) phase three due to reverse causation? 

      ISAAC Phase Three Study Group; González Díaz, Carlos; Pérez-Yarza Pérez-Irezabal, Gorka (Wiley, 2019-04)
      Background: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence of symptoms of asthma in children. We undertook comprehensive analyses addressing risk factors ...
    • Thumbnail

      Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering 

      Ibarretxe Bilbao, Gaskon; Álvarez Díaz, Antonia Ángeles; Cañavate Escribano, María Luz; Hilario Rodríguez, Enrique; Aurrekoetxea Campo, Maitane; Unda Rodríguez, Fernando José (SAGE-Hindawi Access to Research, 2012-03-29)
      The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected ...
    • Thumbnail

      Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies 

      Apraiz García, Aintzane; Boyano López, María Dolores; Asumendi Mallea, Aintzane (MDPI, 2011-03-03)
      Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the ...
    • Thumbnail

      Changes in Surface Tension of Aqueous Humor in Anterior Segment Ocular Pathologies 

      Cabrerizo Núñez, Francisco Javier; Urcola Carrera, Javier Haritz; Vecino Cordero, Elena (MDPI, 2016-09)
      The aim of this study was to identify and determine differences in surface tension (ST) of aqueous humor (AH) in patients with cataract, glaucoma and Fuchs endothelial dystrophy (FED). Two hundred and two samples of AH ...
    • Thumbnail

      Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation 

      López López, Saioa; Smith Zubiaga, Isabel; García de Galdeano Zaldivar, María Alicia; Boyano López, María Dolores; García, Oscar; Gardeazábal, Jesús; Martinez-Cadenas, Conrado; Izagirre Arribalzaga, Neskuts; De la Rúa Vaca, Concepción; Alonso Alegre, Santos (Public Library Science, 2015-08-05)
      We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate ...
    • Thumbnail

      Decreased expression of the β2 integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice 

      Benedicto García, Aitor; Márquez Clavijo, Joana; Herrero, Alba; Olaso Montero, Elvira; Kolaczkowska, Elzbieta; Arteta Ruiz, Beatriz (Biomed Central, 2017-12-06)
      Background: Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this ...
    • Thumbnail

      Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective 

      Cortés Díaz, Jesús María; De Petris, Giovanni; López, José I. (Frontiers Media, 2017-03-06)
      Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version ...
    • Thumbnail

      Dexamethasone Protects Retinal Ganglion Cells But Not Muller Glia Against Hyperglycemia In Vitro 

      Pereiro Díez, Xandra; Ruzafa Andrés, Noelia; Acera Osa, Arantxa; Fonollosa Calduch, Alejandro; Rodríguez, Francisco David; Vecino Cordero, Elena (Public Library Science, 2018-11-26)
      Diabetic retinopathy (DR) is a common complication of diabetes, for which hyperglycemia is a major etiological factor. It is known that retinal glia (Muller cells) and retinal ganglion cells (RGCs) are affected by diabetes, ...
    • Thumbnail

      Effect of Hypoxia on the Retina and Superior Colliculus of Neonatal Pigs 

      Ruzafa Andrés, Noelia; Rey Santano, María Carmen; Mielgo, Victoria; Pereiro Díez, Xandra; Vecino Cordero, Elena (Public LIbrary Science, 2017-04-13)
      Purpose To evaluate the effect of hypoxia on the neonatal pig retina and brain, we analysed the retinal ganglion cells (RGCs) and neurons in the superior colliculus, as well as the response of astrocytes in both these ...
    • Thumbnail

      Effect of Neonatal Asphyxia on the Impairment of the Auditory Pathway by Recording Auditory Brainstem Responses in Newborn Piglets: A New Experimentation Model to Study the Perinatal Hypoxic-Ischemic Damage on the Auditory Syste 

      Álvarez, Francisco José; Revuelta Aramberri, Miren; Santaolalla Montoya, Francisco; Álvarez Díaz, Antonia Ángeles; Lafuente, Héctor; Arteaga Cabeza, Olatz; Alonso Alconada, Daniel; Sánchez del Rey, Ana Salomé; Hilario Rodríguez, Enrique; Martínez Ibargüen, Agustín (Public Library Science, 2015-05-26)
      Introduction Hypoxia-ischemia (HI) is a major perinatal problem that results in severe damage to the brain impairing the normal development of the auditory system. The purpose of the present study is to study the effect ...
    • Thumbnail

      Effect of resveratrol on alcohol-induced mortality and liver lesions in mice 

      Bujanda Fernández de Pierola, Luis; García Barcina, María; Gutiérrez de Juan, Virginia; Bidaurrazaga Van Dierdonck, Joseba; Fernández de Luco, Marian; Gutiérrez Stampa, Marian; Larzabal, Mikel; Hijona Muruamendiaraz, Elizabeth; Sarasqueta, Cristina; Echenique Elizondo, Miguel; Arenas Mirave, Juan Ignacio (BioMed Central, 2006-11-14)
      Background Resveratrol is a polyphenol with important antiinflammatory and antioxidant properties. We investigated the effect of resveratrol on alcohol-induced mortality and liver lesions in mice. Methods Mice were ...
    • Thumbnail

      Estimation of preterm labor immediacy by nonlinear methods 

      Malaina Celada, Iker; Martínez Fernández, Luis; Matorras Weinig, José Roberto; Bringas Roldán, Carlos; Aranburu Laka, Larraitz; Fernández-Llebrez del Rey, Luis; González, Leire; Arana, Itziar; Pérez Pinilla, Martín Blas; Martínez de la Fuente Martínez, Ildefonso Abel (Public Library Science, 2017-06-01)
      Preterm delivery affects about one tenth of human births and is associated with an increased perinatal morbimortality as well as with remarkable costs. Even if there are a number of predictors and markers of preterm delivery, ...
    • Thumbnail

      Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells 

      Apraiz García, Aintzane; Idkowiak-Baldys, Jolanta K.; Boyano López, María Dolores; Pérez-Yarza Pérez-Irezabal, Gorka; Hannun, Yusuf A.; Asumendi Mallea, Aintzane (BioMed Central, 2011-10-07)
      Background -- N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a synthetic retinoid with potent pro-apoptotic activity against several types of cancer, but little is known regarding mechanisms leading to chemoresistance. ...
    • Thumbnail

      Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity 

      Díaz Núñez, María; Díez Torre, Alejandro; De Wever, Olivier; Andrade Pocino, Ricardo; Arluzea de Jauregizar, Jon Andoni; Silió López, Margarita Rosa; Aréchaga Martínez, Juan Miguel (Biomed Central, 2016-08-22)
      Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and ...
    • Thumbnail

      Human DenPulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain 

      Luzuriaga González, Jon; Pastor Alonso, Oier; Encinas, Juan Manuel; Unda Rodríguez, Fernando José; Ibarretxe Bilbao, Gaskon; Pineda Martí, José Ramón (Frontiers Media, 2019-03-28)
      Dental pulp stem cells (DPSCs) have the capacity to give rise to cells with neuronal-like phenotypes, suggesting their use in brain cell therapies. In the present work, we wanted to address the phenotypic fate of adult ...
    • Thumbnail

      Hyaluronic Acid Combined with Serum Rich in Growth Factors in Corneal Epithelial Defects 

      Suárez Barrio, Carlota; Etxebarria, Jaime; Hernáez Moya, Raquel; Del Val Alonso, Marina; Rodríguez Astigarraga, Maddalen; Urkaregi Etxepare, Arantza; Freire Vallejo, Vanesa; Morales González, María Celia; Durán de la Colina, Juan Antonio; Vicario, Marta; Molina, Irene; Herrero Vanrell, Rocío; Andollo Victoriano, María Noelia (MDPI, 2019-04-03)
      The aim of this study is to assess if an adhesive biopolymer, sodium hyaluronate (NaHA), has synergistic effects with s-PRGF (a serum derived from plasma rich in growth factors and a blood derivative that has already shown ...