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      Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties 

      Cochet, Florent; Facchini, Fabio A.; Zaffaroni, Lenny; Billod, Jean-Marc; Coelho, Helena; Holgado, Aurora; Braun, Harald; Beyaert, Rudi; Jerala, Roman; Jiménez Barbero, Jesús; Martin-Santamaria, Sonsoles; Peri, Francesco (Nature Publishing, 2019-01-29)
      New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl ...