Now showing items 1-20 of 112

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      6-Hydroxydopamine lesion and levodopa treatment modif y the effect of buspirone in the substantia nigra pars reticulata 

      Vegas Suárez, Sergio ORCID; Pisanò, Clarissa Anna; Requejo Rodríguez, Catalina ORCID; Bengoetxea Odriozola, Harkaitz; Lafuente Sánchez, José Vicente ORCID; Morari, Michele; Miguelez Palomo, Cristina; Ugedo Urruela, Luisa (Wiley, 2020-09)
      Background and Purpose l-DOPA-induced dyskinesia (LID) is considered a major complication in the treatment of Parkinson's disease (PD). Buspirone (5-HT(1A)partial agonist) have shown promising results in the treatment of ...
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      A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users 

      Mallah, Narmeen; Zapata Cachafeiro, Maruxa; Aguirre Gómez, Carmelo; Ibarra García, Eguzkiñe; Palacios Zabalza, Itziar; Macías Garcia, Fernando; Iglesias García, Julio; Piñeiro Lamas, María; Ibáñez, Luisa; Vidal, Xavier; Vendrell, Lourdes; Martín Arias, Luis; Sainz Gil, María; Velasco González, Verónica; Salgado Barreira, Ángel; Figueiras, Adolfo (Nature Research, 2021-10-07)
      [EN]Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case-control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable ...
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      Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats 

      Borges, Gisela; Miguélez Palomo, Cristina; Neto, Fani; Mico, Juan Antonio; Ugedo Urruela, Luisa; Berrocoso, Esther (Oxford University Press, 2017-06)
      Background: There is increasing evidence suggesting that the Locus Coeruleus plays a role in pain-related anxiety. Indeed, we previously found that prolonged arthritis produces anxiety-like behavior in rats, along with ...
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      Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats 

      Aristieta Arbelaiz, Asier; Ruiz Ortega, José Ángel; Morera Herreras, Teresa; Miguélez Palomo, Cristina; Ugedo Urruela, Luisa (Elsevier, 2019-12)
      The pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with aberrant neuronal activity and abnormal high levels of oscillatory activity and synchronization in several basal ganglia ...
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      Alcohol-Related Brain Damage in Humans 

      Erdozain Fernández, Amaia Maite ORCID; Morentin Campillo, Benito; Bedford, Lynn; King, Emma; Tooth, David; Brewer, Charlotte; Wayne, Declan; Johnson, Laura; Gerdes, Henry K.; Wigmore, Peter; Callado Hernando, Luis Felipe ORCID; Carter, Wayne G. (Public Library Science, 2014-04-03)
      Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control ...
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      Analysis of Mitochondrial Function in Cell Membranes as Indicator of Tissue Vulnerability to Drugs in Humans 

      Elexpe, Ane; Sánchez-Sánchez, Laura; Tolentino-Cortez, Tarson; Astigarraga Arribas, Egoitz; Torrecilla Sesma, María ORCID; Barreda Gómez, Gabriel (MDPI, 2022-04-23)
      Drug side effects are one of the main reasons for treatment withdrawal during clinical trials. Reactive oxygen species formation is involved in many of the drug side effects, mainly by interacting with the components of ...
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      Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry 

      Veloso Fernández, Antonio; Astigarraga Arribas, Egoitz; Barreda Gómez, Gabriel; Manuel Vicente, Iván ORCID; Ferrer, Isidro; Giralt, María Teresa; Ochoa Olascoaga, Begoña; Fresnedo Aranguren, María Olatz; Rodríguez Puertas, Rafael ORCID; Fernández González, José Andrés ORCID (Springer Verlag, 2011-01-28)
      [ES] Las imágenes de masa molecular de los tejidos estarán sesgadas si las diferencias en las propiedades fisicoquímicas del microentorno afectan a la intensidad de los espectros. Para abordar esta cuestión, hemos realizado ...
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      Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain 

      González de San Román, Estibaliz ORCID; Manuel Vicente, Iván ORCID; Giralt, M. Teresa; Chun, Jerold; Estivill Torrús, Guillermo; Rodríguez de Fonseca, Fernando; Santín Núñez, Luis Javier; Ferrer, Isidro; Rodríguez Puertas, Rafael ORCID (John Wiley & Sons, 2015-04-10)
      El ácido lisofosfatídico (LPA) es una molécula de señalización que se une a seis receptores acoplados a proteínas G conocidos: LPA1 -LPA6 . El LPA evoca varias respuestas en el SNC, entre ellas el desarrollo y plegamiento ...
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      Application of a dual mechanistic approach to support bilastine dose selection for older adults 

      Kim, Chaejin; Lo Re, Valentina; Rodríguez, Mónica; Lukas, John; Leal, Nerea; Campo, Cristina; García- Bea, Aintzane; Suárez González, María Elena; Schmidt, Stephan; Vozmediano, Valvanera (Wiley, 2021-09)
      The objective of this study was to evaluate bilastine dosing recommendations in older adults and overcome the limitation of insufficient data from phase I studies in this underrepresented population. This was achieved by ...
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      Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover 

      Plaza Zabala, Ainhoa ORCID; Sierra Torre, Virginia; Sierra Saavedra, Amanda (Frontiers Media, 2021-01-29)
      Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly ...
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      Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia 

      Urigüen Echeverría, Leyre ORCID; Gil Pisa, I.; Munarriz Cuezva, Eva; Berrocoso, E.; Pascau, J.; Soto Montenegro, María Luisa; Gutiérrez Adán, A.; Pintado, B.; Madrigal, J. L. M.; Castro, E.; Sánchez Blázquez, P.; Ortega, J. E.; Guerrero, M. J.; Ferrer Alcon, M.; García Sevilla, J. A.; Mico, J. A.; Desco, M.; Leza, Juan Carlos; Pazos, A.; Garzon, J.; Meana Martínez, José Javier ORCID (Nature Publishing Group, 2013-01)
      Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter ...
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      Buspirone anti-dyskinetic effect is correlated with temporal normalization of dysregulated striatal DRD1 signalling in L-DOPA-treated rats 

      Azkona Mendoza, Garikoitz ORCID; Sagarduy Crespo, Ainhoa ORCID; Aristieta Arbelaiz, Asier; Vazquez, Nerea; Zubillaga, Veronica; Ruiz Ortega, José Ángel; Pérez Navarro, Ester; Ugedo Urruela, Luisa; Sánchez Pernaute, Rosario (Elsevier, 2014-04)
      Dopamine replacement with l-DOPA is the most effective therapy in Parkinson's disease. However, with chronic treatment, half of the patients develop an abnormal motor response including dyskinesias. The specific molecular ...
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      Calcium-binding proteins are altered in the cerebellum in schizophrenia 

      Vidal Domènech, Francisco; Riquelme, Gemma; Pinacho, Raquel; Rodríguez Mias, Ricard; Vera, América; Monje, Alfonso; Ferrer, Isidre; Callado Hernando, Luis Felipe ORCID; Meana Martínez, José Javier ORCID; Villén, Judit; Ramos, Belén (Public Library Science, 2020-07-08)
      Alterations in the cortico-cerebellar-thalamic-cortical circuit might underlie the diversity of symptoms in schizophrenia. However, molecular changes in cerebellar neuronal circuits, part of this network, have not yet been ...
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      Cannabigerol modulates α2-adrenoceptor and 5-HT1A receptor-mediated electrophysiological effects on dorsal raphe nucleus and locus coeruleus neurons and anxiety behavior in rat 

      Mendiguren Ordorica, Aitziber ORCID; Aostri Parga, Erik ORCID; Rodilla Ojeda, Irati ORCID; Pujana, Iker; Noskova, Ekaterina; Pineda Ortiz, Joseba Gotzon ORCID (Frontiers Media, 2023-05)
      The pharmacological profile of cannabigerol (CBG), which acid form constitutes the main precursor of the most abundant cannabinoids, has been scarcely studied. It has been reported to target α2-adrenoceptor and 5-HT1A ...
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      Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome 

      Navarro Romero, Alba; Galera López, Lorena; Ortíz Romero, Paula; Llorente Ovejero, Alberto; de los Reyes Ramírez, Lucía; Bengoetxea de Tena, Iker; García Elías, Anna; Mas-Stachurska, Aleksandra; Reixachs Solé, Marina; Pastor, Antoni; De la Torre, Rafael; Maldonado, Rafael; Benito, Begoña; Eyras, Eduardo; Rodríguez Puertas, Rafael ORCID; Campuzano, Victoria; Ozaita, Andres (eLife Sciences, 2022-10)
      Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular ...
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      Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients 

      Ibarra Lecue, Inés ORCID; Unzueta Larrinaga, Paula; Barrena Barbadillo, Rocío; Villate Uribe, Aitor; Horrillo Furundarena, Igor ORCID; Mendivil, Begoña; Landabaso, Miguel A.; Meana Martínez, José Javier ORCID; Etxebarria Loizate, Nestor; Callado Hernando, Luis Felipe ORCID; Urigüen Echeverría, Leyre ORCID (Wiley, 2022-11)
      Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5-HT2AR) have been involved in psychosis and, like ...
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      CB1 and LPA(1) Receptors Relationship in the Mouse Central Nervous System 

      González de San Román, Estibaliz ORCID; Manuel Vicente, Iván ORCID; Ledent, Catherine; Chun, Jerold; Rodríguez de Fonseca, Fernando; Estivill Torrús, Guillermo; Santín Núñez, Luis Javier; Rodríguez Puertas, Rafael ORCID (Frontiers Media, 2019-09-19)
      Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, ...
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      Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping Out of the Striatum 

      Mallet, Nicolas; Delgado Zabalza, Lorena; Chazalon, Marine; Miguélez Palomo, Cristina; Baufreton, Jérôme (MDPI, 2019-08-29)
      The basal ganglia (BG) are a collection of interconnected subcortical nuclei that participate in a great variety of functions, ranging from motor programming and execution to procedural learning, cognition, and emotions. ...
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      Cellular neurochemical characterization and subcellular localization of Phospholipase C-β1 in rat brain 

      Montaña, Mario; García del Caño, Gontzal; López de Jesús, Maider ORCID; González Burguera, Imanol; Echeazarra, Leyre; Barrondo Lacarra, Sergio ORCID; Sallés Alvira, Joan (Elsevier, 2012-10-11)
      The present study describes a complete and detailed neuroanatomical distribution map of the phospholipase C beta1 (PLCβ1) isoform along the adult rat neuraxis, and defines the phenotype of cells expressing PLCβ1, along ...
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      Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers 

      Requejo Rodríguez, Catalina ORCID; López de Ipiña Peña, Miren Karmele; Ruiz Ortega, José Ángel; Fernández Gómez de Segura, Elsa; Calvo Salomón, Pilar María; Morera Herreras, Teresa; Miguélez Palomo, Cristina; Cardona Grifoll, Laura; Cepeda Berenguer, Hodei; Ugedo Urruela, Luisa; Lafuente Sánchez, José Vicente ORCID (Frontiers Media, 2020-10-14)
      The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ...