BackExaminar Artículos por departamento (eus.) "Genetika,antropologia fisikoa eta animalien fisiologia"
Now showing items 1-20 of 230
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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
; ; Ruiz Núñez, Asier
; ; Arrizabalaga Uriarte, Oskar ; ; Alberdi Alfonso, Elena María ; ; ; ; ; ; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ... -
18S rRNA V9 metabarcoding for diet characterization: a critical evaluation with two sympatric zooplanktivorous fish species
; Aguirre Rodrigo, Mikel; Abad García, David; Santos, María; Estomba Recalde, Miren Andone (Wiley Blackwell, 2016-03)
The potential of the 18S rRNA V9 metabarcoding approach for diet assessment was explored using MiSeq paired-end (PE; 2 9 150 bp) technology. To critically evaluate the method's performance with degraded/digested DNA, the ... -
A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression
(MDPI, 2022-03-21)The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the ... -
A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K
García Santisteban, Iraia; ; ; Urbaneja Arrue, María Ángeles ; ; Bañuelos Rodríguez, Sonia ; Rodríguez Pérez, José Antonio (Springer Nature Switzerland AG, 2016-12)
The exportin CRM1 binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm. Structural and biochemical analyses have uncovered the molecular mechanisms ... -
A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
; ; ; ; ; Santos Zorrozúa, Borja; ; ; ; ; García-Orad Carles, África ; (Ivyspring International Publisher, 2019)
Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field ... -
A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene
; ; Alonso Alegre, Santos; Boyano López, María Dolores ; ; ; ; ; ; ; ; Izagirre Arribalzaga, Neskuts ; De la Rúa Vaca, Concepción ; Asumendi Mallea, Aintzane ; Pérez-Yarza Pérez-Irezabal, Gorka ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Public Library of Science, 2011-04-29)
As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ... -
A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family
García Santisteban, Iraia; Bañuelos Rodríguez, Sonia ; Rodríguez Pérez, José Antonio (Portland Press LTD, 2012-01-01)
The mechanisms that regulate the nucleocytoplasmic localization of human deubiquitinases remain largely unknown. The nuclear export receptor CRM1 binds to specific amino acid motifs termed NESs (nuclear export sequences). ... -
A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells
González Moro, Itziar; ; Sebastián de la Cruz, Maialen ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Frontiers Media, 2023-02)
IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long ... -
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
Fernández Jiménez, Nora; ; Cilleros Portet, Ariadna ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bilbao Catalá, José Ramón (Nature, 2022-11)
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ ... -
A Novel Noninvasive Method Based on Salivary Inflammatory Biomarkers for the Screening of Celiac Disease
Sebastián de la Cruz, Maialen; ; ; ; ; Fernández Jiménez, Nora ; ; ; ; ; ; Irastorza Epelde, Igor ; Bujanda Fernández de Pierola, Luis ; Bilbao Catalá, José Ramón ; (Elsevier, 2021)
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A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
; ; ; ; ; ; Bilbao Catalá, José Ramón (Nature Publishing Group, 2019-12)
N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ... -
A Novel Transcriptome-Derived SNPs Array for Tench (Tinca Tinca L.)
; Langa Arranz, Jorge Eliseo; Montes Asperilla, Iratxe ; ; ; ; Estomba Recalde, Miren Andone (Public Library Science, 2019-03-19)
Tench (Tinca tinca L.) has great economic potential due to its high rate of fecundity and long-life span. Population genetic studies based on allozymes, microsatellites, PCR-RFLP and sequence analysis of genes and DNA ... -
A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes
Ramírez Sánchez, Juan Manuel; Prieto Agujeta, Gorka ; ; ; ; Alduntzin Egizurain, Unai ; Osinalde Moraleja, Nerea ; ; Lectez, Benoît ; ; Rodríguez Pérez, José Antonio ; ; ; ; ; Arizmendi Bastarrika, Jesús María ; Mayor Martínez, Ugo (MDPI, 2021-05-03)
The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ... -
A real-time PCR assay to estimate invertebrate and fish predation on anchovy eggs in the Bay of Biscay
; ; ; ; ; ; Estomba Recalde, Miren Andone (Elsevier, 2014-12-12)
In order to investigate the role of predation on eggs and larvae in the recruitment of anchovy (Engraulis encrasicolus), sardine (Sardina pilchardus), sprat (Sprattus sprattus) and 52 macrozooplankton taxa were assayed for ... -
A Recording Form for Differential Diagnosis of Arthropathies
García Ventades, Nerea; Martín Laza, Imanol ; Hervella Afonso, Montserrat ; De la Rúa Vaca, Concepción (Elsevier, 2018-03)
The present study is focused on a group of arthropathies that may have very similar bone manifestations (rheumatoid arthritis, ankylosing spondylitis, reactive arthritis, psoriatic arthritis, osteoarthritis and diffuse ... -
A short exposure to a semi-natural habitat alleviates the honey bee hive microbial imbalance caused by agricultural stress
; ; ; ; ; ; ; ; Estomba Recalde, Miren Andone; Zarraonaindia Martínez, Iratxe (Nature, 2022-11)
Honeybee health and the species' gut microbiota are interconnected. Also noteworthy are the multiple niches present within hives, each with distinct microbiotas and all coexisting, which we termed "apibiome". External ... -
A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis
Sarasola, Esther; Rodríguez Pérez, José Antonio; Garrote Llanos, María Isabel; Arístegui Fernández, Javier; García-Barcina, María J. (BioMed Central, 2011-06-27)
Background: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive genetic disease characterized by the lack of reaction to noxious stimuli and anhidrosis. It is caused by mutations in the ... -
A statistical investigation into the sharing of common genetic factors between blood pressure and obesity phenotypes in nuclear families from the Greater Bilbao (Spain)
; ; Rebato Ochoa, Esther Matilde (Lippincott, Williams & Wilkins, 2010)
Objectives: Several obesity phenotypes (e.g. body mass and fat, fat distribution) have been suggested to be a risk for elevated blood pressure. This study was undertaken to determine the heritability of four blood pressure ... -
A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia
López López, Elixabet; ; Ballesteros Rodríguez, Francisco Javier ; García-Orad Carles, África (Springer, 2013-10-23)
Methotrexate (MTX) is an important component of therapy used to treat childhood acute lymphoblastic leukemia (ALL). Two single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T ... -
A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes
Garitazelaia González, Aiara; Rueda Martínez, Aintzane; Arauzo, Rebeca; De Miguel, Jokin; Cilleros Portet, Ariadna; Marí Alemany, Sergi; Bilbao Catalá, José Ramón ; Fernández Jiménez, Nora ; García Santisteban, Iraia (MDPI, 2021-01-03)
Endometriosis, one of the most common gynecological disorders, is a complex disease characterized by the growth of endometrial-like tissue in extra-uterine locations and is a cause of pelvic pain and infertility. Evidence ...