Browsing Artículos by Author "Gimeno, Ana"

Now showing items 1-10 of 10

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      Glycan structures and their interactions with proteins. A NMR view 

      Gimeno, Ana; Valverde, Pablo; Ardá, Ana ORCID; Jiménez Barbero, Jesús ORCID (Elsevier, 2019-12)
      Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, ...
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      Glycans in drug discovery 

      Valverde, Pablo; Ardá, Ana ORCID; Reichardt, Niels Christian; Jiménez Barbero, Jesús ORCID; Gimeno, Ana (Royal Soc Chemistry, 2019-07-26)
      Glycans are key players in many biological processes. They are essential for protein folding and stability and act as recognition elements in cell-cell and cell-matrix interactions. Thus, being at the heart of medically ...
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      Selective C-13-Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins 

      Moure, María J.; Gimeno, Ana; Delgado, Sandra; Diercks, Tammo; Boons, Geert-Jan; Jiménez Barbero, Jesús ORCID; Ardá, Ana ORCID (Wiley, 2021-08-16)
      A combined chemo-enzymatic synthesis/NMR-based methodology is presented to identify, in unambiguous manner, the distinctive binding epitope within repeating sugar oligomers when binding to protein receptors. The concept ...
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      Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins 

      Lenza, Maria Pia; Oyenarte Santamaría, Iker; Diercks, Tammo; Quintana García, Jon Imanol; Gimeno, Ana; Coelho, Helena; Diniz, Ana; Peccati, Francesca; Delgado, Sandra; Bosch, Alexandre; Valle, Mikel; Millet Aguilar-Galindo, Oscar; Abrescia, Nicola A.G.; Palazón, Asís; Marcelo, Filipa; Jiménez Oses, Gonzalo; Jiménez Barbero, Jesús ORCID; Ardá, Ana ORCID; Ereño Orbea, June (Wiley, 2020-10)
      The glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed ...
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      Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide 

      Henriques, Pedro; Dello Iacono, Lucia; Gimeno, Ana; Biolchi, Alessia; Romano, Maria Rosaria; Ardá, Ana ORCID; Bernardes, Gonalo J. L.; Jiménez Barbero, Jesús ORCID; Berti, Francesco; Rappuoli, Rino; Adamo, Roberto (National Academy of Sciences, 2020-11-24)
      Meningococcal meningitis remains a substantial cause of mortality and morbidity worldwide. Until recently, countries in the African meningitis belt were susceptible to devastating outbreaks, largely attributed to serogroup ...
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      Synthetic Zwitterionic Streptococcus pneumoniae Type 1 Oligosaccharides Carrying Labile O-Acetyl Esters 

      Wang, Zhen; Gimeno, Ana; Gutiérrez Lete, Marta; Overkleeft, Herman S.; Van der Marel, Gijsbert A.; Chiodo, Fabrizio; Jiménez Barbero, Jesús ORCID; Codee, Jeroen D. C. (Wiley, 2023-01)
      We herein report the first total synthesis of the Streptococcus pneumoniae serotype 1 (Sp1) oligosaccharide, a unique zwitterionic capsular polysaccharide carrying labile O-acetyl esters. The target oligosaccharides, ...
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      Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction 

      Zhang, Qingju; Gimeno, Ana; Santana, Darielys; Wang, Zhen; Valdés Balbín, Yury; Rodríguez Noda, Laura M.; Hansen, Thomas; Kong, Li; Shen, Mengjie; Overkleeft, Herman S.; Verez Bencomo, Vicente; Van der Marel, Gijsbert A.; Jiménez Barbero, Jesús ORCID; Chiodo, Fabrizio; Codee, Jeroen D. C. (American Chemical Society, 2019-08-28)
      The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide (Sp1) is an important anchor point for our immune system to act against streptococcal infections. Antibodies can recognize Sp1 saccharides, and it has ...
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      Targeting Galectins With Glycomimetics 

      Bertuzzi, Sara; Quintana, Jon I.; Ardá, Ana ORCID; Gimeno, Ana; Jiménez Barbero, Jesús ORCID (Frontiers Media, 2020-08-07)
      Among glycan-binding proteins, galectins, beta-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation. Their involvement in crucial pathologies ...
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      The two domains of human galectin-8 bind sialyl- and fucose-containing oligosaccharides in an independent manner. A 3D view by using NMR 

      Gómez Redondo, Marcos; Delgado, Sandra; Núñez Franco, Reyes; Jiménez Oses, Gonzalo; Ardá, Ana ORCID; Jiménez Barbero, Jesús ORCID; Gimeno, Ana (Royal Society of Chemistry, 2021-06-01)
      The interaction of human galectin-8 and its two separate N-terminal and C-terminal carbohydrate recognition domains (CRD) to their natural ligands has been analysed using a synergistic combination of experimental NMR and ...
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      Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1 

      Bertuzzi, Sara; Gimeno, Ana; Núñez Franco, Reyes; Bernardo Seisdedos, Ganeko; Delgado, Sandra; Jiménez Oses, Gonzalo; Millet Aguilar-Galindo, Oscar; Jiménez Barbero, Jesús ORCID; Ardá, Ana ORCID (Wiley, 2020-12-01)
      The interaction of human galectin-1 with a variety of oligosaccharides, from di-(N-acetyllactosamine) to tetra-saccharides (blood B type-II antigen) has been scrutinized by using a combined approach of different NMR ...