Now showing items 1-2 of 2

    • Thumbnail

      iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology 

      Matamoros-Angles, Andreu; Mayela Gayosso, Lucía; Richaud-Patin, Yvonne; Di Domenico, Angelique; Vergara, Cristina; Hervera, Arnau; Sousa, Amaya; Fernández-Borges, Natalia; Consiglio, Antonella; Gavín, Rosalina; López de Maturana, Rakel; Ferrer, Isidro; López de Munain Arregui, Adolfo José; Raya, Ángel; Castilla, Joaquín; Sánchez-Pernaute, Rosario; Del Río, José Antonio (Humana Press, 2018-04)
      Gerstmann-Straussler-Scheinker (GSS) syndrome is a fatal autosomal dominant neurodegenerative prionopathy clinically characterized by ataxia, spastic paraparesis, extrapyramidal signs and dementia. In some GSS familiar ...
    • Thumbnail

      Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons 

      López de Maturana, Rakel; Lang, Valérie; Zubiarrain, Amaia; Sousa, Amaya; Vázquez, Nerea; Gorostidi, Ana; Águila, Julio; López de Munain Arregui, Adolfo José; Rodríguez, Manuel; Sánchez-Pernaute, Rosario (Biomed Central, 2016-11-18)
      Background: Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is ...