Now showing items 1-5 of 5

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      Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours 

      Solano Iturri, Jon Danel; Echevarría Orella, Enrique ORCID; Unda Urzaiz, Jesús Miguel; Loizaga Iriarte, Ana; Pérez Fernández, Amparo; Angulo, Javier C.; López Fernández de Villaverde, José Ignacio ORCID; Larrinaga Embeita, Gorka ORCID (MDPI, 2021-02-10)
      (1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour ...
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      Integrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Cancer 

      Valcárcel Jiménez, Lorea; Macchia, Alice; Martín Martín, Natalia; Cortázar, Ana Rosa; Schaub Clerigué, Ariane; Pujana Vaquerizo, Mikel; Fernández Ruiz, Sonia; Lacasa Viscasillas, Isabel; Santos Martín, Aida; Loizaga Iriarte, Ana; Unda Urzaiz, Jesús Miguel; Hermanova, Ivana; Astobiza Pérez, Janire; Graupera, Mariona; Julia, Starkova; Sutherland, James D.; Barrio Olano, María Rosa; Aransay Bañares, Ana María; Carracedo Pérez, Arkaitz ORCID; Torrano Moya, Verónica (Nature Publishing Group, 2018-10-11)
      The dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity ...
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      Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression 

      Clos García, Marc; Loizaga Iriarte, Ana; Zuñiga García, Patricia; Sánchez Mosquera, Pilar; Cortázar, Ana Rosa; González, Esperanza; Verónica Torrano; Alonso, Cristina; Pérez Cormenzana, Miriam; Ugalde Olano, Aitziber; Lacasa Viscasillas, Isabel; Castro, Azucena; Royo, Félix; Unda Urzaiz, Jesús Miguel; Carracedo Pérez, Arkaitz ORCID; Falcón Pérez, Juan Manuel (Taylor & Francis, 2018-05-07)
      Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have ...
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      PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer 

      Zabala Letona, Amaia; Arruabarrena Aristorena, Amaia; Fernández Ruiz, Sonia; Viera, Cristina; Carlevaris, Onintza; Ercilla Eguiarte, Amaia; Mendizabal, Isabel; Martín Mateos, Teresa; Macchia, Alice; Camacho Soguero, Laura; Pujana Vaquerizo, Mikel; Sánchez Mosquera, Pilar; Torrano Moya, Verónica; Martín Martín, Natalia; Zuñiga García, Patricia; Castillo Martín, Mireia; Ugalde Olano, Aitziber; Loizaga Iriarte, Ana; Unda Urzaiz, Jesús Miguel; Mato, José M.; Berra Ramírez, Miren Edurne; Martínez Chantar, María Luz ORCID; Carracedo Pérez, Arkaitz ORCID (Springer Nature, 2022-02)
      [EN] Glycine N-Methyltransferase (GNMT) is a metabolic enzyme that integrates metabolism and epigenetic regulation. The product of GNMT, sarcosine, has been proposed as a prostate cancer biomarker. This enzyme is predominantly ...
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      Soluble PD-L1 Is an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma 

      Larrinaga Embeita, Gorka ORCID; Solano Iturri, Jon Danel; Errarte Yarza, Peio; Unda Urzaiz, Jesús Miguel; Loizaga Iriarte, Ana; Pérez Fernández, Amparo; Echevarría Orella, Enrique ORCID; Asumendi Mallea, Aintzane ORCID; Manini, Claudia; Angulo, Javier C.; López Fernández de Villaverde, José Ignacio ORCID (MDPI, 2021-02-07)
      (1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response to immune checkpoint inhibitors. We evaluated ...