BackBrowsing Artículos by Author "Lopitz Otsoa, Fernando"
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A Morphological Method for Ammonia Detection in Liver
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz
(Public Library Science, 2017-03-20)
Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a common event in acute liver injury/ failure and chronic liver disease. Even though hepatic ammonia levels are potential predictive ... -
Analysis of SUMOylated proteins using SUMO-traps
Da Silva Ferrada, Elisa; Xolalpa, Wendy; Lang, Valerie; Aillet, Fabienne; Martín-Ruiz, Itziar; De la Cruz-Herrera, Carlos F.; Lopitz Otsoa, Fernando; Carracedo Pérez, Arkaitz; Goldenberg, Seth J.; Rivas, Carmen; England, Patrick; Rodríguez, Manuel S. (Nature Publishing Group, 2013-04-22)
SUMO-modified proteins are recognized by SUMO interacting motifs (SIMs), thus triggering diverse cellular responses. Here SIMs were used to develop SUMO-traps to capture endogenous SUMOylated proteins. Our results show ... -
Anti-miR-518d-5p Overcomes Liver Tumor Cell Death Resistance Through Mitochondrial Activity
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María; ; ; ; ; ; ; Martínez Chantar, María Luz (Springer Nature, 2021-05-28)
Dysregulation of miRNAs is a hallmark of cancer, modulating oncogenes, tumor suppressors, and drug responsiveness. The multi-kinase inhibitor sorafenib is one of the first-line drugs for advanced hepatocellular carcinoma ... -
Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
Fernández Ramos, David; Lopitz Otsoa, Fernando; De la Cruz Villar, Laura; Bilbao García, Jon; Pagano, Martina; Mosca, Laura; Bizkarguenaga, Maider; ; ; Iruarrizaga Lejarreta, Marta; Sot, Jesús; Tsvirkun, Darya; Van Liempd, Sebastiaan Martijn; Goñi Urcelay, Félix María; Alonso, Cristina; Martínez Chantar, María Luz ; ; Hayardeny, Liat; Lu, Shelly C.; Mato, José M. (Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ... -
Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ... -
Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez de Marigorta Izaga, Edorta; ; ; ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; ; ; ; (Wiley, 2022-10)
Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors. Approach and ... -
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
Fernández Tussy, Pablo; Fernández Ramos, David; Lopitz Otsoa, Fernando; Simon, Jorge; Barbier Torres, Lucía; Gómez Santos, Beatriz; Nuñez García, Maitane; ; ; Gutiérrez de Juan, Virginia; ; Rodríguez Agudo, Rubén; Iruzubieta, Paula; Anguita Castillo, Juan de Dios; Castro, Rui E.; Champagne, Devin; Rincon, Mercedes; ; Arslanow, Anita; Krawczyk, Marcin; Lammert, Frank; Kirchmeyer, Melanie; Behrmann, Iris; Crespo, Javier; Lu, Shelly C.; Mato, José M.; Varela Rey, Marta; ; Delgado, Teresa C.; Martínez Chantar, María Luz (Elsevier, 2019-08-16)
Objective: Non-alcoholic fatly liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metabolic pathways, mitochondrial functionality and unbalanced lipid import/export, lead ... -
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
; ; ; ; ; ; ; ; ; ; ; ; Arizmendi Bastarrika, Jesús María; ; ; ; Ávila, Matías A. ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; Mayor Martínez, Ugo ; Martínez Chantar, María Luz ; (MDPI, 2020-11-27)
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ... -
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Ávila, Matías A.; ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2019-02)
BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular ...