Browsing Artículos by Author "Manini, Claudia"

Now showing items 1-6 of 6

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      Clear Cell Renal Cell Carcinoma: A Test Bench for Investigating Tumor Complexity 

      Manini, Claudia; López Fernández, Estíbaliz; Larrinaga Embeita, Gorka ORCID; López Fernández de Villaverde, José Ignacio ORCID (MDPI, 2024-02-19)
      Clear cell renal cell carcinoma (CCRCC), by far the most common renal cancer subtype, is an aggressive tumor variant, serving in recent years as a prolific test bench in cancer research [...]
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      Early Evolution in Cancer: A Mathematical Support for Pathological and Genomic Evidence in Clear Cell Renal Cell Carcinoma 

      Laruelle, Annick ORCID; Manini, Claudia; López Fernández de Villaverde, José Ignacio ORCID; Rocha, André (MDPI, 2023-12-18)
      Clear cell renal cell carcinoma (CCRCC) is an aggressive form of cancer and a paradigmatic example of intratumor heterogeneity (ITH). The hawk-dove game is a mathematical tool designed to analyze competition in biological ...
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      Effects of Heterogeneity on Cancer: A Game Theory Perspective 

      Laruelle, Annick ORCID; Barreira da Silva Rocha, André; Manini, Claudia; López Fernández de Villaverde, José Ignacio ORCID; Iñarra García, María Elena ORCID (Springer, 2023-08)
      In this study, we explore interactions between cancer cells by using the hawk–dove game. We analyze the heterogeneity of tumors by considering games with populations composed of 2 or 3 types of cell. We determine what ...
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      Metastasis, an Example of Evolvability 

      Laruelle, Annick ORCID; Manini, Claudia; Iñarra García, María Elena ORCID; López Fernández de Villaverde, José Ignacio ORCID (MDPI, 2021-06-21)
      This overview focuses on two different perspectives to analyze the metastatic process taking clear cell renal cell carcinoma as a model, molecular and ecological. On the one hand, genomic analyses have demonstrated up to ...
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      Soluble PD-L1 Is an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma 

      Larrinaga Embeita, Gorka ORCID; Solano Iturri, Jon Danel; Errarte Yarza, Peio; Unda Urzaiz, Jesús Miguel; Loizaga Iriarte, Ana; Pérez Fernández, Amparo; Echevarría Orella, Enrique ORCID; Asumendi Mallea, Aintzane ORCID; Manini, Claudia; Angulo, Javier C.; López Fernández de Villaverde, José Ignacio ORCID (MDPI, 2021-02-07)
      (1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response to immune checkpoint inhibitors. We evaluated ...
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      The Labyrinth of Renal Cell Carcinoma 

      Manini, Claudia; López Fernández de Villaverde, José Ignacio ORCID (MDPI, 2020-02-24)
      Renal cell carcinoma (RCC) ranks in the top-ten list of malignancies both in males and females [...]