Now showing items 1-15 of 15

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      A genealogical map of the concept of habit 

      Barandiaran Fernández, Xabier Eugenio; Di Paolo, Ezequiel (Frontiers Research Foundation, 2014-07-21)
      The notion of information processing has dominated the study of the mind for over six decades. However, before the advent of cognitivism, one of the most prominent theoretical ideas was that of Habit. This is a concept ...
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      A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report 

      Rodríguez Martínez, Ana B.; Garrido, Joseba M.; Zarranz Imirizaldu, Juan José; Arteagoitia, Jose M.;; Martínez de Pancorbo Gómez, María de los Angeles; Atares, Begona;; Bilbao, Miren J.;; Ferrer, Isidro;; Juste, Ramon A.; (BioMed Central, 2010-10)
      Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are ...
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      Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model : mechanism for deficient glutamatergic transmission? 

      Olabarria, Markel; Noristani, Harun N.; Verkhratsky, Alexei; Rodríguez Arellano, José Julio (BioMed Central, 2011-07-30)
      Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal ...
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      Behavioral profile of adults with Prader-Willi syndrome : correlations with individual and environmental variables 

      Jauregu Picabea, Joseba; Laurier, Virginie; Copet, Pierre; Tauber, Maithé; Thuilleaux, Denise (BioMed Central, 2013)
      Background: Maladaptive behavior has been reported as a phenotypical feature in Prader–Willi syndrome (PWS). It severely limits social adaptation and the quality of life of children and adults with the syndrome. Different ...
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      Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS 

      Noristani, Harun Najib; Sabourin, Jean Charles; Gerber, Yannick Nicolas; Teigell, Marisa; Sommacal, Andreas; Vivanco, Maria dM; Weber, Markus; Perrin, Florence (Biomed Central, 2015-08-01)
      Background: There is growing evidence that microglia are key players in the pathological process of amyotrophic lateral sclerosis (ALS). It is suggested that microglia have a dual role in motoneurone degeneration through ...
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      Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain 

      Gil de la Pisa, Itziar; Cebrián, Carolina; Ortega Calvo, Jorge; Meana Martínez, José Javier; Sulzer, David (Biomed Central, 2014-07-29)
      Background: An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be ...
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      Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease 

      Yeh, Chia-Yu; Vadhwana, Bhamini; Verkhratsky, Alexei; Rodríguez Arellano, José Julio (Portland Press, 2011)
      The EC (entorhinal cortex) is fundamental for cognitive and mnesic functions. Thus damage to this area appears as a key element in the progression of AD (Alzheimer's disease), resulting in memory deficits arising from ...
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      Enactivism is not interactionism 

      De Jaegher, Hanneke; Di Paolo, Ezequiel (Frontiers Research Foundation, 2013-01)
      ...
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      FTY720 attenuates excitotoxicity and neuroinflammation 

      Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez Antigüedad, Alfredo; Matute Almau, Carlos José (BioMed Central, 2015-05-08)
      Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...
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      Increased expression of cystine/glutamate antiporter in multiple sclerosis 

      Pampliega Ormaetxea, Olatz; Domercq García, María; Soria Lannes, Federico Nicolás; Villoslada, Pablo; Rodríguez-Antigüedad, Alfredo; Matute Almau, Carlos José (BioMed Central, 2011-06-03)
      Background: Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which ...
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      Learning to perceive in the sensor motor approach: Piaget's theory of equilibration interpreted dynamically 

      Di Paolo, Ezequiel; Barandiaran Fernández, Xabier Eugenio; Beaton, Michael James Stuart; Buhrmann, Thomas (Frontiers Research Foundation, 2014-07-30)
      Learning to perceive is faced with a classical paradox: if understanding is required for perception, how can we learn to perceive something new, something we do not yet understand? According to the sensorimotor approach, ...
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      Modeling habits as self-sustaining patterns of sensorimotor behavior 

      Egbert, Matthew D; Barandiaran Fernández, Xabier Eugenio (Frontiers Research Foundation, 2014-08-08)
      In the recent history of psychology and cognitive neuroscience, the notion of habit has been reduced to a stimulus-triggered response probability correlation. In this paper we use a computational model to present an ...
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      Risk factors for dementia in the epidemiological study of Munguialde County (Basque Country-Spain) 

      Fernández Martínez, Manuel; Castro Flores, Jessica; Pérez de las Heras, Susana; Mandaluniz Lekumberri, Aitziber; Gordejuela Menocal, María; Zarranz Imirizaldu, Juan José (BioMed Central, 2008-10-15)
      Background: Prevalence of degenerative dementias and dementias associated with cerebrovascular disease is increasing. Dementia is one of the most significant public health problem. In recent years, the role of vascular ...
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      Systematic review of pharmacological treatments in fragile X syndrome 

      Rueda Martínez de Santos, José Ramón; Ballesteros Rodríguez, Francisco Javier; Tejada, María Isabel (BioMed Central, 2009-10-13)
      Background: Fragile X syndrome (FXS) is considered the most common cause of inherited mental retardation. Affected people have mental impairment that can include Attention Deficit and/or Hyperactivity Disorder (ADHD), ...
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      The interactive brain hypothesis 

      Di Paolo, Ezequiel; De Jaegher, Hanneke (Frontiers Research Foundation, 2012-06)
      Enactive approaches foreground the role of interpersonal interaction in explanations of social understanding. This motivates, in combination with a recent interest in neuroscientific studies involving actual interactions, ...