Now showing items 1-7 of 7

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      Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation 

      Nunes Xavier, Caroline E.; Zaldumbide Dueñas, Laura; Aurtenetxe, Olaia; López Almaraz, Ricardo; López Fernández de Villaverde, José Ignacio ORCID; Pulido Murillo, Rafael (MDPI, 2019-03-01)
      Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) ...
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      Identification and Functional Analysis of a Novel CTNNB1 Mutation in Pediatric Medulloblastoma 

      Alaña, Lide; Nunes Xavier, Caroline E.; Zaldumbide Dueñas, Laura; Martín Guerrero, Idoia; Mosteiro González, Lorena; Alba Pavón, Piedad; Villate, Olatz; García Obregón, Susana; González García, Hermenegildo; Herraiz, Raquel; Astigarraga Aguirre, María Iciar; Pulido Murillo, Rafael; García Ariza, Miguel Angel (MDPI, 2022-01-14)
      Medulloblastoma is the primary malignant tumor of the Central Nervous System (CNS) most common in pediatrics. We present here, the histological, molecular, and functional analysis of a cohort of 88 pediatric medulloblastoma ...
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      MMADHC Premature Termination Codons in the Pathogenesis of Cobalamin D Disorder: Potential of Translational Readthrough Reconstitution 

      Torices, Leire; De las Heras Montero, Javier Adolfo; Arango Lasprilla, Juan Carlos; Cortés Díaz, Jesús María; Nunes Xavier, Caroline E.; Pulido Murillo, Rafael (Elsevier, 2021-03)
      Mutations in the MMADHC gene cause cobalamin D disorder (cblD), an autosomal recessive inborn disease with defects in intracellular cobalamin (cbl, vitamin B12) metabolism. CblD patients present methylmalonic aciduria ...
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      (Pro)renin Receptor Is a Novel Independent Prognostic Marker in Invasive Urothelial Carcinoma of the Bladder 

      Larrinaga Embeita, Gorka ORCID; Calvete Candenas, Julio; Solano Iturri, Jon Danel; Martín, Ana M.; Pueyo, Angel; Nunes Xavier, Caroline E.; Pulido Murillo, Rafael; Dorado, Juan F.; López Fernández de Villaverde, José Ignacio ORCID; Angulo, Javier C. (MDPI, 2021-11-11)
      (Pro)renin receptor (PRR) is being investigated in several malignancies as it activates pathogenic pathways that contribute to cell proliferation, immunosuppressive microenvironments, and acquisition of aggressive neoplastic ...
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      Protein tyrosine phosphatase modulates cell growth and associates with poor outcome in human neuroblastoma 

      Nunes Xavier, Caroline E.; Aurtenetxe, Olaia; Zaldumbide Dueñas, Laura; López Almaraz, Ricardo; Erramuzpe Aliaga, Asier; Cortés Díaz, Jesús María; López Fernández de Villaverde, José Ignacio ORCID; Pulido Murillo, Rafael (BMC, 2019-12-14)
      Background Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the ...
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      The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases 

      Errarte Yarza, Peio; Guarch, Rosa; Pulido Murillo, Rafael; Blanco Criado, Lorena; Nunes Xavier, Caroline E.; Beitia San Vicente, Maider; Gil Goicouría, Francisco Javier ORCID; Angulo, Javier C.; López Fernández de Villaverde, José Ignacio ORCID (Public Library Science, 2016-12-29)
      Clear cell renal cell carcinoma (CCRCC) is a heterogeneous and complex disease that frequently develops distant metastases. Fibroblast activation protein (FAP) is a serine peptidase the expression of which in cancer-associated ...
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      The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma 

      Nunes Xavier, Caroline E.; Emaldi, Maite; Mingo Gómez de Oteo, Janire; Øyjord, Tove; Mælandsmo, Gunhild M.; Fodstad, Øystein; Errarte Yarza, Peio; Larrinaga Embeita, Gorka ORCID; Llarena Ibarguren, Roberto; López, José I.; Pulido Murillo, Rafael (Nature, 2023-05)
      Renal cancer cells constitute a paradigm of tumor cells with a glycolytic reprogramming which drives metabolic alterations favouring cell survival and transformation. We studied the expression and activity of pyruvate ...