Now showing items 1-13 of 13

    • Thumbnail

      1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

      Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier; Apraiz, A.; Arrizabalaga Uriarte, Oskar; Vellon, L.; Alberdi Alfonso, Elena María; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
      1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
    • Thumbnail

      A genealogical map of the concept of habit 

      Barandiaran Fernández, Xabier Eugenio; Di Paolo, Ezequiel (Frontiers Research Foundation, 2014-07-21)
      The notion of information processing has dominated the study of the mind for over six decades. However, before the advent of cognitivism, one of the most prominent theoretical ideas was that of Habit. This is a concept ...
    • Thumbnail

      Antioxidant defense system and family environment in adolescents with family history of psychosis 

      González Pinto Arrillaga, Ana María; Martínez Cengotitabengoa, Mónica; Arango, Celso; Baeza, Inmaculada; Otero Cuesta, Soraya; Graell Berna, Montserrat; Soutullo, César; Leza, Juan Carlos; Micó, Juan Antonio (BioMed Central, 2012-11-16)
      [EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with ...
    • Thumbnail

      Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia 

      Urigüen Echeverría, Leyre; Gil Pisa, I.; Munarriz Cuezva, Eva; Berrocoso, E.; Pascau, J.; Soto Montenegro, M. L.; Gutiérrez Adán, A.; Pintado, B.; Madrigal, J. L. M.; Castro, E.; Sánchez Blázquez, P.; Ortega, J. E.; Guerrero, M. J.; Ferrer Alcon, M.; García Sevilla, J. A.; Mico, J. A.; Desco, M.; Leza, Juan Carlos; Pazos, A.; Garzon, J.; Meana Martínez, José Javier (Nature Publishing Group, 2013-01)
      Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter ...
    • Thumbnail

      Cannabis use and involuntary admission may mediate long-term adherence in first-episode psychosis patients: a prospective longitudinal study 

      Barbeito, Sara; Vega, Patricia; Ruiz de Azúa Garcia, Sonia; Sáenz, Margarita; Martínez Cengotitabengoa, Mónica; González Ortega, Itxaso; Bermúdez, Cristina; Hernanz, Margarita; Fernández de Corres, Blanca; González Pinto Arrillaga, Ana María (BioMed Central, 2013-12-01)
      Background: This study aimed to examine factors associated with treatment adherence in first-episode psychosis (FEP) patients followed up over 8 years, especially involuntary first admission and stopping cannabis use. Methods: ...
    • Thumbnail

      Enactivism is not interactionism 

      De Jaegher, Hanneke; Di Paolo, Ezequiel (Frontiers Research Foundation, 2013-01)
    • Thumbnail

      Factors associated with chronic pain in patients with bipolar depression: a cross-sectional study 

      Failde, Inmaculada; Dueñas Chasco, María Teresa; Agüera Ortíz, Luis; Cervilla, Jorge A.; González Pinto Arrillaga, Ana María; Mico, Juan A. (BioMed Central, 2013-04-15)
      Background: While pain is frequently associated with unipolar depression, few studies have investigated the link between pain and bipolar depression. In the present study we estimated the prevalence and characteristics of ...
    • Thumbnail

      Learning to perceive in the sensor motor approach: Piaget's theory of equilibration interpreted dynamically 

      Di Paolo, Ezequiel; Barandiaran Fernández, Xabier Eugenio; Beaton, Michael James Stuart; Buhrmann, Thomas (Frontiers Research Foundation, 2014-07-30)
      Learning to perceive is faced with a classical paradox: if understanding is required for perception, how can we learn to perceive something new, something we do not yet understand? According to the sensorimotor approach, ...
    • Thumbnail

      Modeling habits as self-sustaining patterns of sensorimotor behavior 

      Egbert, Matthew D; Barandiaran Fernández, Xabier Eugenio (Frontiers Research Foundation, 2014-08-08)
      In the recent history of psychology and cognitive neuroscience, the notion of habit has been reduced to a stimulus-triggered response probability correlation. In this paper we use a computational model to present an ...
    • Thumbnail

      Number of prior episodes and the presence of depressive symptoms are associated with longer length of stay for patients with acute manic episodes 

      Martín Carrasco, Manuel; González Pinto Arrillaga, Ana María; Galán, Jaime L.; Ballesteros Rodríguez, Francisco Javier; Maurino, Jorge; Vieta, Eduard (BioMed Central, 2012-03-10)
      Background: Few studies have analyzed predictors of length of stay (LOS) in patients admitted due to acute bipolar manic episodes. The purpose of the present study was to estimate LOS and to determine the potential ...
    • Thumbnail

      Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis 

      Ruiz de Azúa Garcia, Sonia; Matute Almau, Carlos José; Stertz, Laura; Mosquera, Fernando; Palomino Fernández de Larrea, Aitor; De la Rosa, Iris; Barbeito, Sara; Vega, Patricia; Kapczinski, Flavío; González Pinto Arrillaga, Ana María (BioMed Central, 2013)
      Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain ...
    • Thumbnail

      Reduced antioxidant defense in early onset first-episode psychosis: a case-control study 

      Mico, Juan Antonio; Rojas Corrales, Maria Olga; Gibert Rahola, Juan; Parellada, Mara; Moreno, Dolores; Fraguas, David; Graell Berna, Montserrat; Gil Goicouría, Francisco Javier; Irazusta Astiazaran, Jon; Castro Fornieles, Josefina; Soutullo, César; Arango, Celso; Otero, Soraya; Navarro, Ana; Baeza, Inmaculada; Martínez Cengotitabengoa, Mónica; González Pinto Arrillaga, Ana María (BioMed Cental, 2011)
      Background Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group. Methods Total antioxidant status ...
    • Thumbnail

      The interactive brain hypothesis 

      Di Paolo, Ezequiel; De Jaegher, Hanneke (Frontiers Research Foundation, 2012-06)
      Enactive approaches foreground the role of interpersonal interaction in explanations of social understanding. This motivates, in combination with a recent interest in neuroscientific studies involving actual interactions, ...