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      High Thyrotropin Is Critical for Cardiac Electrical Remodeling and Arrhythmia Vulnerability in Hypothyroidism 

      Fernández Ruocco, Julieta; Gallego Muñoz, Mónica ORCID; Rodríguez de Yurre, Ainhoa; Zayas Arrabal, Julián; Echeazarra Escudero, Leire; Alquiza Etxabe, Amaia; Fernández López, Víctor; Rodríguez Robledo, Juan Manuel; Brito, Oscar; Schleier, Ygor; Sepúlveda, Marisa; Oshiyama, Natalia F.; Vila Petroff, Martin; Bassani, Rosana A.; Medei, Emiliano; Casis Sáenz, Oscar ORCID (Mary Ann Liebert, 2019-07-17)
      Background: Hypothyroidism, the most common endocrine disease, induces cardiac electrical remodeling that creates a substrate for ventricular arrhythmias. Recent studies report that high thyrotropin (TSH) levels are related ...
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      Kv1.3 Channel Blockade Improves Inflammatory Profile, Reduces Cardiac Electrical Remodeling, and Prevents Arrhythmia in Type 2 Diabetic Rats 

      Zayas Arrabal, Julián; Alquiza Etxabe, Amaia; Rodríguez de Yurre, Ainhoa; Echeazarra Escudero, Leire; Fernández López, Víctor; Gallego Muñoz, Mónica ORCID; Casis Sáenz, Oscar ORCID (Springer, 2023-02)
      Purpose Kv1.3 channel regulates the activity of lymphocytes, macrophages, or adipose tissue and its blockade reduces inflammatory cytokine secretion and improves insulin sensitivity in animals with metabolic syndrome and ...
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      Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model 

      Rodríguez de Yurre, Ainhoa; Martins, Eduarda G. L.; López Alarcón, Micaela; Cabral, Bruno; Vera, Narendra; Lopes, Jarlene A.; Galina, Antonio; Takiya, Christina M; Lindoso, Rafael S.; Vieyra, Adalberto; Casis Sáenz, Oscar ORCID; Medei, Emiliano (Academia Brasileira de Ciencias, 2020)
      Type 2 diabetes mellitus (T2DM) is associated with an increase of premature appearance of several disorders such as cardiac complications. Thus, we test the hypothesis that a combination of a high fat diet (HFD) and low ...