Now showing items 1-7 of 7

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      A Computational Analysis of Protein-Protein Interaction Networks in Neurodegenerative Diseases 

      Goñi Cortés, Joaquín; Esteban Ruiz, Francisco J.; Vélez de Mendizábal, Nieves; Sepulcre, Jorge; Ardanza Trevijano, Sergio; Agirrezabal, Ion; Villoslada, Pablo (Biomed Central, 2008-06-20)
      Background: Recent developments have meant that network theory is making an important contribution to the topological study of biological networks, such as protein-protein interaction (PPI) networks. The identification of ...
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      A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation 

      Di Penta, Alessandra; Chiba, Asako; Alloza Moral, Iraide; Wyssenbach Ibarra, Ane; Yamamura, Takashi; Villoslada, Pablo; Miyake, Sachiko; Vandenbroeck, Koen (Public Library of Science, 2013-12-11)
      Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving ...
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      Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine 

      Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; Matute Almau, Carlos José; Sánchez Gómez, María Victoria; Domercq García, María; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
      Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...
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      Increased expression of cystine/glutamate antiporter in multiple sclerosis 

      Pampliega Ormaetxea, Olatz; Domercq García, María; Soria Lannes, Federico Nicolás; Villoslada, Pablo; Rodríguez-Antigüedad Zarranz, Alfredo; Matute Almau, Carlos José (BioMed Central, 2011-06-03)
      Background: Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which ...
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      Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases 

      Moreno, B.; Di Penta, Alessandra; Kerschensteiner, M.; Matute Almau, Carlos José; Ceña, V.; López, I.; Alberch, Jordi; Parent, J.; Serra, J.; Errea, O.; Villoslada, Pablo (BioMed Central, 2010-11-25)
      Background Methylthioadenosine (MTA) has anti-oxidant and anti-proliferative properties and was shown to induce cell protection in hepatic cells. We previously demonstrated that exert immunomodulatory and neuroprotective ...
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      Modeling the Effector - Regulatory T Cell Cross-Regulation Reveals the Intrinsic Character of Relapses in Multiple Sclerosis 

      Vélez de Mendizabal, Nieves; Carneiro, Jorge; Solé, Ricard V.; Goñi, Joaquín; Bragard, Jean; Martínez Forero, Ivan; Martínez Pasamar, Sara; Sepulcre, Jorge; Torrealdea Folgado, Francisco Javier; Bagnato, Francesca; Garcia Ojalvo, Jordi; Villoslada, Pablo (Biomed Central, 2011-07-15)
      Background: The relapsing-remitting dynamics is a hallmark of autoimmune diseases such as Multiple Sclerosis (MS). Although current understanding of both cellular and molecular mechanisms involved in the pathogenesis of ...
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      Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation 

      Di Penta, Alessandra; Moreno, Beatriz; Reix, Stephanie; Fernández Díez, Begoña; Villanueva, Maite; Errea, Oihana; Escala, Nagore; Vandenbroeck, Koen; Comella, Joan X.; Villoslada, Pablo (Public Library of Science, 2013-02-19)
      Background: Demyelination and axonal damage are critical processes in the pathogenesis of multiple sclerosis (MS). Oxidative stress and pro-inflammatory cytokines elicited by inflammation mediates tissue damage. Metho ...